Skip to main content

Table 4 Genotypic association of significant SNPs with coronary artery disease

From: Analysis of 61 SNPs from the CAD specific genomic loci reveals unique set of SNPs as significant markers in the Southern Indian population of Hyderabad

SNP

Genotype

Frequency

OR(95% CI)

p value

Best model (p value)

Cases n(%)

Controls n(%)

rs10455872

AA

AG

GG

193 (57.96)

140 (42.04)

0 (0)

468(98.53)

7(1.47)

0(0)

Reference

48.5(22.3–105)

NA

 < 0.0001

NA

Co dominant (NA)

rs6725887

TT

TC

CC

251 (72.54)

89 (25.72)

6 (1.73)

455(95.99)

19(4.033)

0(0)

Reference

8.49(5.05–14.3)

23.5(1.32–419)

 < 0.0001

0.032

Log-additive (5.21e−21)

rs782590

CC

CT

TT

175 (50.72)

130 (37.68)

40 (11.59)

292(61.99)

149(31.63)

30(6.37)

Reference

1.45(1.08–1.97)

2.22(1.34–3.70)

0.014

0.002

Log-additive (0.0004323)

rs173539

CC

CT

TT

226 (93.77)

12 (4.98)

3 (1.24)

361(97.83)

8(2.17)

0(0)

Reference

2.40(0.96–5.95)

11.2(0.57–217)

0.060

0.111

Log-additive (0.011648)

rs9818870

CC

CT

TT

293 (85.17)

47 (13.66)

4 (1.16)

381(80.04)

85(17.86)

10(2.10)

Reference

0.72(0.49–1.06)

0.52(0.16–1.67)

0.095

0.273

Log-additive (0.2571)

  1. Bold indicates significant p value/odds ratio