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Table 2 Association of significant SNPs with the anatomical categories of coronary artery disease

From: Analysis of 61 SNPs from the CAD specific genomic loci reveals unique set of SNPs as significant markers in the Southern Indian population of Hyderabad

SNP (minor/major allele)

MAF in controls N = 480

Insignificant (n = 81)

Single vessel disease (n = 98)

Double vessel disease (n = 70)

Triple vessel disease (n = 66)

MAF

OR (95%CI)

p value

MAF

OR (95%CI)

p value

MAF

OR (95%CI)

p value

MAF

OR (95%CI)

p value

rs10455872 (G/A)

0.007

0.234

41.2 (17.9–94.4)

*1.22e−41

0.177

29.1 (12.6–66.8)

*1.22e−30

0.164

26.5 (11.1–63.3)

*6.20e−26

0.206

35.0 (14.8–82.7)

*4.38e−34

rs6725887 (C/T)

0.020

0.198

12.0 (6.63–21.9)

*2.03e−23

0.119

6.58 (3.51–12.3)

*3.09e−11

0.123

6.87 (3.48–13.6)

*2.56e−10

0.138

7.86 (4.01–15.4)

*3.53e−12

rs173539 (T/C)

    

0.054

5.19 (1.85–14.6)

*0.0005

0.042

3.97 (1.17–13.4)

0.017

0.048

4.56 (1.34–15.5)

0.008

rs782590 (T/C)

    

0.295

1.47 (1.03–2.07)

0.030

0.377

2.12 (1.45–3.09)

*7.16e−5

   

rs247617 (A/C)

0.259

   

0.333

1.43 (1.02–1.99)

0.036

   

0.356

1.58 (1.07–2.32)

0.019

rs2107595 (T/C)

0.325

   

0.216

0.57 (0.39–0.83)

*0.003

      

rs3127599 (A/G)

0.205

   

0.274

1.46 (1.03–2.09)

0.035

      

rs9940128 (A/G)

0.440

         

0.326

0.61 (0.42–0.90)

0.013

rs1083096 (C/G)

0.468

         

0.364

0.65 (0.44–0.95)

0.024

  1. Bold indicates significant p value (of the odds ratio)
  2. *p value significant after correction for multiple testing