Skip to main content

Table 1 Allelic association of significant SNPs with coronary artery disease

From: Analysis of 61 SNPs from the CAD specific genomic loci reveals unique set of SNPs as significant markers in the Southern Indian population of Hyderabad

SNP ID Chr/gene location Alleles Minor allele frequency (MAF) χ2 Unadjusted Adjusted for age and sex
Minor/major Cases (N = 350) Controls (N = 480)   OR (CI 95%) p value OR (CI 95%) p value
rs10455872* 6/ LPA G/A 0.210 0.007 194.8 35.9 (16.7–77.2) 2.83e−44 60.0 (26.7–134) 3.54e−23
rs6725887* 2/WDR12 C/T 0.416 0.020 93.5 8.36 (5.16–13.8) 4.04e−22 8.58 (5.09–14.5) 7.22e−16
rs782590* 2/SMEK1 T/C 0.304 0.222 14.2 1.53 (1.23–1.92) 0.0002 1.51 (1.21–1.88) 0.0003
rs173539* 16/HERPUD1-CETP T/C 0.037 0.011 9.8 3.54 (1.53–8.21) 0.002 2.86 (1.27–6.45) 0.011
rs9818870 3/MRAS T/C 0.080 0.110 4.2 0.70 (0.50–0.99) 0.041 0.69 (0.49–0.97) 0.032
  1. LPA, lipoprtein A; WDR12, WD repeat domian12; SMEK1, serine/threonine protein phosphatase/suppressor of mek1; HERPUD1-CETP, homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1-cholesteryl ester transfer protein; MRAS, muscle RAS oncogene homolog
  2. *SNP significant after correction for multiple testing