Table 2 Echocardiographic and laboratory parameters

LV parameters

LVEDV—ml

142 [100–195]

92 [68–115]

134 [98–168]

194 [151–230]

 < 0.01

LVESV—ml

82 [52–121]

38 [30–48]

70 [53–94]

128 [102–164]

 < 0.01

LV mass index—gram/m2

106 [89–132]

94 [82–120]

101 [86–121]

120 [97–139]

 < 0.01

LVEF—%

44 [34–49]

57 [56–60]

47 [45–48]

33 [26–38]

 < 0.01

LA parameters

LAVI—ml/m2

37 [28–47]

39 [32–46]

32 [25–40]

41 [34–52]

 < 0.01

LAS_r—%

27 [20–35]

27 [24–32]

33 [26–39]

23 [14–30]

 < 0.01

RV parameters

TAPSE—cm

2 [0.47]

2.1 [0.48]

2.0 [0.40]

1.9 [0.50]

0.08

Peak TR gradient—mmHg*

26 [20–34]

30 [26–38]

21 [18–5]

29 [22–36]

 < 0.01

Valvular heart disease

Aortic stenosis ≥ moderate

6 [3%]

2 [5%]

0 [0%]

4 [5%]

0.12

Aortic regurgitation ≥ moderate

3 [2%]

0 [0%]

2 [3%]

1 [1%]

0.60

Mitral stenosis ≥ moderate

0 [0%]

0 [0%]

0 [0%]

0 [0%]

-

Mitral regurgitation ≥ moderate

31 [18%]

5 [14%]

4 [6%]

22 [29%]

< 0.01

Tricuspid regurgitation ≥ moderate

8 [5%]

1 [3%]

0 [0%]

7 [9%]

0.02

Laboratory biomarkers

CKD-EPI—mL/min

68 (22)

59 (16)

74 (21)

67 (23)

 < 0.01

NT-proBNP—pg/mL

568 [276–1114]

568 [298–925]

357 [138–706]

788 [449–1913]

 < 0.01