Common genetic variants do not predict recurrent events in coronary heart disease patients

Table 5 Testing the GRS published by Mega et al. [8] using the same 27 SNPs to predict the same outcomes (CHD death, non-fatal MI, UAP, CABG and PCI) at 2 years

Model	27 SNP GRS of Mega et al. added to the model
Model	NRI	Baseline C-statistic	C-statistic + SNPs
Base model: hypertension, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, diabetes, sex, age, current smoking	0.097	0.69	0.70
Base model as above with history of CHD included	0.064	0.67	0.69
Base model as above with history of prior MI included (0 = none, 1 = one, 2 = multiple)	0.067	0.69	0.70

Effect on NRI and C-statistic determined after adding the previously published GRS to three different models
CHD coronary heart disease, MI myocardial infarction

ISSN: 1471-2261