Common genetic variants do not predict recurrent events in coronary heart disease patients

Table 4 Levels of risk of CHD deaths over 10 years and recurrent CHD events over 2 years, when applying the Mega et al. ^¥ GRS to the LIPID Genetic cohort

Variable	Level of risk	No/total %events	Unadjusted for risk factors			Adjusted for risk factors as in Mega et al.^¥¥
Variable	Level of risk	No/total %events	HR (95% CI)	p Value	Overall p value	HR (95% CI)	p Value	Overall p value
CHD death over 10 years	Low	142/976 (15%)	1		0.99	1		0.59
	Moderate	429/2928 (15%)	1.01 (0.84, 1.22)	0.92		1.02 (0.85, 1.24)	0.81
	High	144/976 (15%)	1.01 (0.80, 1.28)	0.90		1.12 (0.86, 1.41)	0.35
CHD events ^¥ as described in Mega et al. (10) over 2 years	Low	102/976 (10%)	1		0.39	1		0.29
	Moderate	328/2928 (11%)	1.13 (0.91, 1.41)	0.27		1.14 (0.92, 1.43)	0.23
	High	116/976 (12%)	1.20 (0.92, 1.57)	0.18		1.23 (0.94, 1.61)	0.12

Low, moderate or high levels of risk were determined by the risk score for each patient, calculated from the previously published 27 SNP GRS of Mega et al. (8) The hazard ratios (mean with 95% CI) compare the low risk (lowest quintile) with moderate risk (middle 3 quintiles) and high-risk (top quintile) categories
The results are shown unadjusted and then adjusted for the same baseline variables used in calculation of the Mega et al. [8] GRS
(^¥¥ history of hypertension, diabetes mellitus, sex, age, current smoking, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol.) High-risk = top quintile, moderate risk = middle 3 quintiles, low risk = bottom quintile. ^¥CHD events as defined by Mega et al. were CHD death, non-fatal MI, unstable angina pectoris, coronary artery bypass graft and percutaneous coronary intervention). CI confidence interval, HR hazard ratio

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