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Table 4 Univariate and bivariate Cox hazard proportional analyses of hemodynamics for all-cause mortality

From: Risk prediction in pulmonary hypertension due to chronic heart failure: incremental prognostic value of pulmonary hemodynamics

Variables

Unadjusted HR (95% CI)

P value

SHFM-adjusted HR (95% CI)

P value*

MAGGIC-adjusted HR (95% CI)

P value*

mRAP (per 1 mmHg increase)

1.045 (0.981–1.113)

0.200

1.046 (0.982–1.114)

1

1.057 (0.989–1.129)

1

RVSP (per 10 mmHg increase)

1.280 (1.069–1.531)

0.007

1.280 (1.067–1.535-)

0.096

1.273 (1.062–1.527)

0.108

RVEDP (per 5 mmHg increase)

1.127 (0.935–1.359)

0.209

1.113 (0.925–1.340)

1

1.137 (0.935–1.382)

1

sPAP (per 10 mmHg increase)

1.313 (1.091–1.581)

0.004

1.299 (1.075–1.570)

0.084

1.279 (1.057–1.548)

0.144

dPAP (per 5 mmHg increase)

1.232 (1.059–1.435)

0.007

1.230 (1.056–1.433)

0.96

1.281 (1.097–1.495)

0.024

mPAP (per 5 mmHg increase)

1.189 (1.048–1.349)

0.007

1.187 (1.042–1.353)

0.120

1.203 (1.058–1.367)

0.060

PAWP (per 1 mmHg increase)

0.985 (0.927–1.045)

0.609

0.989 (0.934–1.046)

1

0.998 (0.941–1.059)

1

DPG (per 1 mmHg increase)

1.066 (1.027–1.106)

< 0.001

1.067 (1.024–1.113)

0.024

1.069 (1.026–1.114)

0.012

PVR (per 1 WU increase)

1.037 (0.983–1.093)

0.189

1.045 (0.989–1.104)

1

1.040 (0.985–1.098)

1

Cardiac index (per 1 L/min/m2 increase)

1.317 (0.938–1.849)

0.112

1.466 (1.030–2.088)

0.408

1.792 (1.228–2.615)

0.024

PAC (per mL/mmHg increase)

0.928 (0.856–1.006)

0.068

0.920 (0.848–0.998)

0.540

0.937 (0.865–1.014)

1

SvO2 (per 5% increase)

0.857 (0.789–0.913)

< 0.001

0.969 (0.953–0.985)

0.002

0.970 (0.954–0.986)

0.004

  1. P values < 0.05 shown in bold
  2. HR, hazard ratio; CI, confidence interval; SHFM, the Seattle heart failure model; MAGGIC, Meta-Analysis Global Group in Chronic Heart Failure; mRAP, mean right atrial pressure; RVSP, right ventricle systolic pressure; RVEDP, right ventricular end diastolic pressure; sPAP, systolic pulmonary artery pressure; dPAP, diastolic pulmonary artery pressure; mPAP, mean pulmonary artery pressure; PAWP, pulmonary arterial wedge pressure; DPG, diastolic pressure gradient; PVR, pulmonary vascular resistance; PAC, pulmonary arterial compliance; SvO2, mixed venous oxygen saturation
  3. *P value after Bonferroni correction