Hyperlipidemia and hypertension have synergistic interaction on ischemic stroke: insights from a general population survey in China

Table 3 Logistic regression models of the combined effect of HLP and HTN on ischemic stroke

	Non-HTN		HTN		HTN by HLP status
	No. of cases/non-cases of ischemic stroke	OR (95% CI)	No. of cases/non-cases of ischemic stroke	OR (95% CI)	OR (95% CI)
Unadjusted model
Non-HLP	86/3879	1	212/3018	3.168 (2.455–4.089), p < 0.001	3.168 (2.455–4.089), p < 0.001
HLP	59/1764	1.509 (1.078–2.111), p = 0.016	310/2367	5.907 (1.078–2.111), p < 0.001	3.916 (2.944–5.208), p < 0.001
HLP by HTN status		1.509 (1.078–2.111), p = 0.016		1.864 (1.553–2.238), p < 0.001
Model 1
Non-HLP	86/3879	1	212/3018	2.087 (1.604–2.716), p < 0.001	2.087 (1.604–2.716), p < 0.001
HLP	59/1764	1.383 (0.986–1.940), p = 0.06	310/2367	3.974 (3.092–5.108), p < 0.001	2.900 (2.165–3.884), p < 0.001
HLP within strata of HTN		1.383 (0.986–1.940), p = 0.06		1.896 (1.575–2.283), p < 0.001
Model 2
Non-HLP	86/3879	1	212/3018	1.995 (1.526–2.610), p < 0.001	1.995 (1.526–2.610), p < 0.001
HLP	59/1764	1.321 (0.937–1.862), p = 0.112	310/2367	3.369 (2.579–4.402), p < 0.001	2.605 (1.926–3.523), p < 0.001
HLP within strata of HTN		1.321 (0.937–1.862), p = 0.112		1.708 (1.406–2.076), p < 0.001

Model 1: adjusted for age and sex
Model 2: adjusted for age, sex, race, education level, family income, current smoking and drinking status, physical activity, BMI, diabetes, family history of stroke, and atrial fibrillation
CI, confidence interval; HLP, hyperlipidemia; HTN, hypertension; OR, odds ratio

ISSN: 1471-2261