Table 1 Baseline levels and prevalence of risk factors of the study population at four overlapping periods shrinking towards the end of follow-up
Follow-up interval | 0–43 years | 25–43 years | 30–43 years | 35–43 years |
|---|---|---|---|---|
Number of patients, n | 7494 | 4491 | 3297 | 2019 |
Aorta events n (%) | 242 (3.2%)1 | 149 (3.3%)1 | 94 (2.9%)1 | 42(2.1%)1 |
Follow up (years) | ||||
Mean (SD) | 26.86 (10.50)1 | 9.09 (5.08)1 | 6.46 (3.63)1 | 3.97 (2.00)1 |
Baseline levels and factors at screening 1970–1973 | ||||
Age (years) | ||||
Mean (SD) | 51.07 (2.28)1 | 50.80 (2.30)1 | 50.56 (2.30)1 | 50.25 (2.28)1 |
Weight (kg) | ||||
Mean (SD) | 78.85 (11.37)3 | 78.66 (10.62)2 | 78.60 (10.44)1 | 78.50 (10.26)1 |
Weight gain, 30 (kg) | ||||
Mean (SD) | 9.84 (9.47) 3 | 9.52 (8.79) 2 | 9.30 (8.53)1 | 9.05 (8.19)1 |
Missing | 467 | 245 | 162 | 87 |
BMI (kg/m2) | ||||
Mean (SD) | 25.54 (3.27)3 | 25.42 (3.01)2 | 25.37(2.95)1 | 25.28 (2.85)1 |
Obesity (BMI ≥ 30 kg/m2), n (%) | 617 (8.2%)3 | 296 (6.6%)2 | 203 (6.2%)1 | 113 (5.6%)1 |
Systolic blood pressure, mmHg | ||||
Mean (SD) | 148.77 (21.94) | 146.37 (21.08) | 145.18 (20.50) | 143.75 (20.08) |
Missing | 12 | 4 | 2 | 1 |
Diastolic blood pressure, mmHg | ||||
Mean (SD) | 94.64 (12.94) | 93.40 (12.43) | 92.76 (12.30) | 92.08 (12.01) |
Missing | 13 | 5 | 2 | 1 |
Heart rate, beats/min | ||||
Mean (SD) | 73.21 (13.53) | 71.99 (12.86) | 71.41 (12.59) | 70.96 (12.86) |
Missing | 40 | 19 | 8 | 4 |
Pulse pressure, mmHg | ||||
Mean (SD) | 54.14 (14.82) | 52.96 (14.30) | 52.41 (13.96) | 51.67 (13.82) |
Missing | 14 | 5 | 2 | 1 |
Cholesterol, mmol/L | ||||
Median (IQR) | 6.32 (1.46) | 6.32 (1.33) | 6.32 (1.46) | 6.21 (1.46) |
Missing | 78 | 29 | 15 | 9 |
Smoking, n (%) | ||||
Never | 2201 (29.4%)1 | 1546 (34.4%)1 | 1222 (37.1%)1 | 837 (41.5%)1 |
Current | 3768 (50.3%)1 | 1923 (42.8%)1 | 1302 (39.5%)1 | 674 (33.4%)1 |
Former | 1524 (20.3%)1 | 1021 (22.7%)1 | 772 (23.4%)1 | 507 (25.1%)1 |
Sedentary life, n (%) | 1919 (25.6)1 | 1002 (22.3)1 | 701 (21.3)1 | 399 (19.8)1 |
Family history of myocardial infarction, parents1 n (%) | 1505 (20.1%)1 | 859 (19.1%)1 | 618 (18.7%)1 | 378 (18.7%)1 |
Family history of stroke, parents1 n (%) | 440 (5.9%)1 | 216 (4.8%)1 | 141 (4.3%)1 | 71 (3.5%)1 |
Family history of myocardial infarction, siblings1 n (%) | 1989(26.5) | 1152(25.7) | 815(24.7) | 473(23.4) |
Family history of stroke, siblings1 n (%) | 196(2.6) | 96(2.1) | 67(2.0) | 38(1.9) |
Time-updated diagnoses 1970–2012 | ||||
Hypertension n (%) | 3690 (49.2%)1 | 2098 (46.7%)1 | 1576 (47.8%)1 | 1030 (51.0%)1 |
Diabetes n (%) | 149 (2.0%)1 | 285 (6.3%)1 | 270 (8.2%)1 | 200 (9.9%)1 |
Ischemic heart disease n (%) | 1131 (15.1%)1 | 1232 (27.4%)1 | 1014 (30.8%)1 | 681 (33.7%)1 |
Stroke n (%) | 43 (0.6%)1 | 318 (7.1%)1 | 362 (11.0%)1 | 262 (13.0%)1 |
Atrial fibrillation n (%) | 4 (0.1%)1 | 376 (8.4%)1 | 481 (14.6%)1 | 391 (19.4%)1 |
Renal failure n (%) | 1 (0.0%)1 | 427 (9.5%)1 | 524 (15.9%)1 | 419 (20.8%)1 |
Heart failure n (%) | 0 (0.0%)1 | 302 (6.7%)1 | 375 (11.4%)1 | 291 (14.4%)1 |