Fig. 1

The image illustrates the pedigree, sequencing analysis, and chromatogram of the index family carrying the mutation, c.G681C, in the DTNA gene. A The pedigree of the proband revealed a positive family history of AF and MI. The genotype of the proband and his family members for DTNA transition demonstrated that the proband (III-5), his brother (III-1), and his brother’s children (IV-2 and IV-5) carried the c.G681C mutation of the DTNA gene in a heterozygote form. The other brother (III-3) and his children (IV-3 and IV-4), who were clinically normal, carried the wild type (G) of the nucleotide. B and C The chromatogram of the wild type (homozygote) and the mutant (heterozygote) of the identified transition is depicted respectively in the upper panel and the lower panel. AF: Atrial Fibrillation, MI: Myocardial Infarction