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Table 5 Analysis of factors related to thrombocytopenia

From: Safety profile of bivalirudin in Chinese female patients undergoing percutaneous coronary intervention: a multi-center study

Items

Thrombocytopenia

Univariate

Multivariate

No (%)

Yes (%)

P value

OR (95% CI)

P value

OR (95% CI)

Age

  

0.324

 

–

 

  > 75 years

222 (96.1)

9 (3.9)

 

1.507 (0.667–3.402)

 

–

  ≤ 75 years

669 (97.4)

18 (2.6)

 

Reference

 

–

BMI

  

0.285

 

–

 

  > 28 kg/m2

86 (98.9)

1 (1.1)

 

0.334 (0.045–2.493)

 

–

  ≤ 28 kg/m2

747 (96.6)

26 (3.4)

 

Reference

 

–

History of diabetes mellitus

  

0.970

 

–

 

 Yes

267 (97.1)

8 (2.9)

 

0.984 (0.425–2.276)

 

–

 No

624 (97.0)

19 (3.0)

 

Reference

 

–

History of allergy

  

0.247

 

–

 

 Yes

100 (95.2)

5 (4.8)

 

1.798 (0.666–4.853)

 

–

 No

791 (97.3)

22 (2.7)

 

Reference

 

–

History of cardiac surgery

  

0.181

 

–

 

 Yes

68 (94.4)

4 (5.6)

 

2.105 (0.708–6.262)

 

–

 No

823 (97.3)

23 (2.7)

 

Reference

 

–

History of renal function impairment

  

0.181

 

–

 

 Yes

25 (92.6)

2 (7.4)

 

2.771 (0.622–12.347)

 

–

 No

866 (97.2)

25 (2.8)

 

Reference

 

–

History of critical respiratory disease

  

0.587

 

–

 

 Yes

19 (95.0)

1 (5.0)

 

1.765 (0.228–13.689)

 

–

 No

872 (97.1)

26 (2.9)

 

Reference

 

–

Clinical presentation-UA

  

0.032

 

0.187

 

 Yes

355 (98.6)

5 (1.4)

 

0.343 (0.129–0.915)

 

0.492 (0.171–1.412)

 No

536 (96.1)

22 (3.9)

 

Reference

 

Reference

Clinical presentation-STEMI

  

0.895

 

–

 

 Yes

319 (97.0)

10 (3.0)

 

1.055 (0.477–2.331)

 

–

 No

572 (97.1)

17 (2.9)

 

Reference

 

–

Clinical presentation-NSTMI

  

0.656

 

–

 

 Yes

126 (97.7)

3 (2.3)

 

0.759 (0.225–2.558)

 

–

 No

765 (97.0)

24 (3.0)

 

Reference

 

–

Clinical presentation-SCAD

  

 < 0.001

 

0.002

 

 Yes

90 (90.9)

9 (9.1)

 

4.450 (1.942–10.198)

 

4.388 (1.754–10.981)

 No

801 (97.8)

18 (2.2)

 

Reference

 

Reference

CRUSADE risk stratification

  

0.122

 

–

 

 High risk

237 (95.6)

11 (4.4)

 

1.854 (0.848–4.052)

 

–

 No high risk

639 (97.6)

16 (2.4)

 

Reference

 

–

Operative timing

  

0.767

 

–

 

 Elective operation

553 (97.2)

16 (2.8)

 

0.889 (0.408–1.938)

 

–

 Emergency operation

338 (96.8)

11 (3.2)

 

Reference

 

–

Types of coronary interventional therapy

  

0.665

 

–

 

 Stent implantation

846 (97.0)

26 (3.0)

 

0.672 (0.111–4.056)

 

–

 Others

45 (97.8)

1 (2.2)

 

Reference

 

–

Types of stents

  

0.410

 

–

 

 Drug stent

835 (97.1)

25 (2.9)

 

0.419 (0.053–3.313)

 

–

 Others

14 (93.3)

1 (6.7)

 

Reference

 

–

Arterial access

  

0.163

 

–

 

 Radial artery

825 (97.3)

23 (2.7)

 

0.460 (0.155–1.370)

 

–

 Others

66 (94.3)

4 (5.7)

 

Reference

 

–

Culprit vessel

  

0.022

 

0.010

 

 Multiple

192 (94.6)

11 (5.4)

 

2.503 (1.143–5.483)

 

2.974 (1.302–6.792)

 Single

699 (97.8)

16 (2.2)

 

Reference

 

Reference

Administration of bivalirudin-preoperative or intraoperative

  

0.036

 

0.081

 

 Yes

28 (90.3)

3 (9.7)

 

3.853 (1.095–13.553)

 

3.220 (0.867–11.953)

 No

863 (97.3)

24 (2.7)

 

Reference

 

Reference

Administration of bivalirudin-postoperative ≤ 4 h

  

0.962

 

–

 

 Yes

756 (97.0)

23 (3.0)

 

1.027 (0.350–3.016)

 

–

 No

135 (97.1)

4 (2.9)

 

Reference

 

–

Administration of bivalirudin-postoperative > 4 h

  

0.216

 

–

 

 Yes

107 (99.1)

1 (0.9)

 

0.282 (0.038–2.098)

 

–

 No

784 (96.8)

26 (3.2)

 

Reference

 

–

Combined with GP IIb/IIIa inhibitors

  

0.281

 

–

 

 Yes

641 (96.7)

22 (3.3)

 

1.716 (0.643–4.581)

 

–

 No

250 (98.0)

5 (2.0)

 

Reference

 

–

TIMI flow grade (pre–procedure)

  

0.074

 

–

 

 2–3

517 (97.9)

11 (2.1)

 

0.492 (0.226–1.072)

 

–

 0–1

370 (95.9)

16 (4.1)

 

Reference

 

–

TIMI flow grade (post-procedure)

  

0.999

 

–

 

 2–3

882 (97.0)

27 (3.0)

 

–

 

–

 0–1

8 (100.0)

0 (0.0)

 

–

 

–

  1. Bold value means statistically significant
  2. OR, odds ratio; CI, confidence interval; BMI, body mass indexes; UA, unstable angina; STEMI, ST-segment elevation myocardial infarction; NSTMI, non-ST-segment elevation myocardial infarction; SCAD, spontaneous coronary artery dissection; CRUSADE, Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the ACC/AHA Guidelines; GP, glycoprotein; TIMI, thrombolysis in myocardial infarction