Table 4 Details of studies included in systematic review and meta-analysis
References, study design | State, health system, number of hospitals | Total number of patients | Myocardial Injury N (%) | No myocardial injury N (%) | Troponin assay used | Patient population | Main finding |
|---|---|---|---|---|---|---|---|
Lala et al. [10], Retrospective | New York, Mount Sinai Health System, 5 | 2736 | 985 (36) | 1751 (64) | Cardiac troponin I (Abbott Architect) | Hospitalized | COVID-19 patients with CVD were more likely to have myocardial injury than patients without CVD. Troponin elevation among patients hospitalized with COVID-19 was associated with higher risk of mortality |
Majure et al. [11] Retrospective | New York, Northwell Health System 13 | 6247 | 1821 (29) | 4426 (71) | cardiac troponin I (Siemens Dimension Vista; Siemens Dimension EXL Systems); cardiac troponin T (Roche Troponin T STAT, 4th generation; Elecys Troponin T Gen 5 STAT) | Hospitalized | Patients hospitalized with COVID-19 and elevated troponin had increased mortality compared with patients with normal troponin levels, which was independent of cardiovascular co-morbidities and elevated inflammatory markers |
Case et al. [12] Retrospective | Maryland (& Washington D.C.) MedStar Health System 11 | 2716 | 250 (9.2) | 2466 (90.8) | Troponin I | Hospitalized | COVID-19 patients with troponin elevation were at higher risk for mechanical ventilation and in-hospital mortality |
De Michieli et al. [13] Retrospective | Minnesota, Wisconsin, Florida, Arizona Mayo Clinic Health System 17 | 367 | 169 (46) | 198 (54) | Hs-cardiac troponin T (Elecys Troponin T Gen 5 STAT) | Hospitalized | Myocardial injury is prognostic in COVID-19 patients with regard to short-term mortality and major adverse events. A single hs-cTnT < 6 ng/L at presentation was associated with a more favorable prognosis |
Pachtman Shetty et al. [14] Retrospective | New York Northwell Health 7 | 18 | 4 (22) | 14 (78) | Hs-Trop, Troponin T, Troponin I | Pregnant and immediately postpartum hospitalized for COVID-19 | Among pregnant women hospitalized for COVID-19, 20% were found to have elevations in troponin and 30% had elevated BNP |
Metkus et al. [9] Retrospective | Maryland, Johns Hopkins Health System 5 | 243 | 124 (51) | 119 (49) | Troponin T or Troponin I | COVID-19 patients who required intubation | Myocardial injury in patients with severe COVID-19 was a function of comorbidities, age, and multisystem organ dysfunction Myocardial injury was associated with > twofold hazard for death |
Changal (2021) Retrospective* | Ohio, Promedica Health System 2 | 258 | 58 (22.5) | 210 (77.5) | Troponin I (Sunquest) | Hospitalized COVID-19 patients | Myocardial injury was common, and predicted mortality, poor outcomes, and discharge to skilled nursing facility |