Table 3 Univariate and multivariate analysis for factors associated with myocardial injury
Clinical factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
Odds ratio | 95% confidence interval | P value | Odds ratio | 95% confidence interval | P value | |
Age (years) | 1.06 | 1.04–1.08 | < 0.001 | 1.05 | 1.02–1.1 | 0.00 |
Sex | 1.01 | 0.56–1.80 | 0.981 | – | – | – |
Hypertension | 3.06 | 1.37–6.81 | 0.006 | 1.37 | 0.56–3.36 | 0.48 |
Diabetes mellitus | 1.33 | 0.73–2.40 | 0.354 | – | – | – |
Cardiovascular disease | 4.12 | 2.24–7.56 | < 0.001 | 2.0 | 1.1–4.0 | 0.04 |
Ischemic heart disease | 2.82 | 1.46–5.44 | 0.002 | – | – | – |
HFrEF | 4.67 | 1.50–14.49 | 0.008 | – | – | – |
HFpEF | 3.04 | 1.31–7.05 | 0.009 | – | – | – |
Atrial fibrillation | 3.39 | 1.49–7.73 | 0.004 | – | – | – |
ESRD on HD | 7.07 | 1.99–25.07 | 0.002 | 6.62 | 1.7–25 | 0.06 |
Hospital course and clinical outcome | ||||||
EKG findings | ||||||
Arrhythmia | 5.46 | 2.47–12.07 | < 0.001 | 3.04 | 1.1–9.3 | 0.04 |
Atrial fibrillation | 3.53 | 1.49–8.37 | 0.004 | – | – | – |
1st degree heart block | 1.84 | 0.33–10.30 | 0.488 | – | – | – |
New BBB | 0.75 | 0.24–2.28 | 0.606 | – | – | – |
ST depression or T wave inversion | 2.34 | 1.09–4.97 | 0.027 | – | – | – |
QT prolongation | 2.08 | 1.11–3.90 | 0.022 | – | – | – |
Abnormal EKG | 3.47 | 1.90–6.34 | < 0.001 | – | – | – |
Abnormal BNP | 4.95 | 2.27–10.82 | < 0.001 | 3.03 | 1.3–7.2 | 0.01 |
High d-dimer | 2.40 | 1.11–5.20 | 0.026 | 1.2 | 0.4–3.5 | 0.73 |
Acute kidney injury | 6.54 | 3.39–12.62 | < 0.001 | 4.5 | 1.8–11 | 0.001 |
Invasive ventilation | 1.35 | 0.66–2.75 | 0.408 | – | – | – |
Shock of any type | 3.70 | 1.85–7.39 | < 0.001 | – | – | – |
ARDS | 1.44 | 0.67–3.08 | 0.354 | – | – | – |
Ischemic stroke | 3.73 | 0.23–60.61 | 0.354 | – | – | – |
Length of stay | 0.99 | 0.96–1.03 | 0.865 | – | – | – |
Do not resuscitate and Comfort care | 4.66 | 2.49–8.71 | < 0.001 | – | – | – |
Discharge to skilled Nursing facility | 2.94 | 1.41–6.10 | 0.004 | – | – | – |
Death | 4.25 | 2.09–8.61 | < 0.001 | – | – | – |
In hospital medications | ||||||
Hydroxychloroquine | 0.73 | 0.39–1.36 | 0.316 | – | – | – |
Anticoagulation | 1.76 | 1.01–3.06 | 0.046 | – | – | – |
ACEi/ARNi | 0.47 | 0.18–1.27 | 0.14 | – | – | – |
Steroids | 3.73 | 1.84–7.57 | < 0.001 | – | – | – |