Table 1 Clinical Characteristics of Patients with Suspected CAD (Cohort A)
All | Major ECG abnormalitya | Minor ECG abnormalitya | No ECG abnormality | P value | |
|---|---|---|---|---|---|
(n = 349) | (n = 106) | (n = 121) | (n = 122) | ||
Age, years | 68.3 ± 10.9 | 67.5 ± 11.2 | 68.0 ± 11.0 | 69.4 ± 10.7 | 0.41 |
Men | 163 (46.7) | 51 (48.1) | 47 (38.8) | 65 (53.3) | 0.07 |
Body mass index kg/m2 | 26.9 ± 4.4 | 26.3 ± 4.2 | 27.7 ± 4.7 | 26.7 ± 4.3 | 0.04† |
Systolic blood pressure, mmHg | 136.2 ± 19.4 | 134.1 ± 19.4 | 137.7 ± 21.1 | 136.62 ± 17.5 | 0.38 |
Diastolic blood pressure, mmHg | 73.5 ± 12.1 | 73.2 ± 12.1 | 74.3 ± 12.7 | 73.0 ± 11.7 | 0.69 |
Heart rate, beats/minute | 77.9 ± 13.7 | 77.9 ± 15.2 | 77.9 ± 13.6 | 77.8 ± 12.5 | 0.99 |
Typical angina | 40 (11.5) | 14 (13.2) | 11 (9.1) | 15 (12.3) | 0.59 |
Atypical angina | 106 (30.4) | 27 (25.5) | 39 (32.2) | 40 (32.8) | 0.42 |
Dyspnea | 53 (15.2) | 17 (16.0) | 17 (14.1) | 19 (15.6) | 0.91 |
History of heart failure | 34 (9.7) | 16 (15.1) | 10 (8.3) | 8 (6.6) | 0.08 |
CAD risk factors | |||||
Hypertension | 317 (90.8) | 95 (89.6) | 109 (90.1) | 113 (92.6) | 0.7 |
Hyperlipidemia | 275 (78.8) | 81 (76.4) | 99 (81.8) | 95 (77.9) | 0.58 |
Diabetes mellitus | 202 (57.9) | 64 (60.4) | 72 (59.5) | 66 (54.1) | 0.57 |
Cigarette smoking | 61 (17.5) | 29 (27.4) | 14 (11.6) | 18 (14.8) | 0.01*† |
Pretest probability of obstructive CAD, % | |||||
Diamond-forrester | 20.3 ± 10.9 | 19.7 ± 10.7 | 18.6 ± 10.5 | 22.6 ± 11.2 | 0.01*‡ |
CAD consortium, clinical model | 30.3 ± 20.4 | 29.7 ± 19.3 | 28.2 ± 20.9 | 32.8 ± 20.9 | 0.2 |
Medications | |||||
ACEI or ARB | 150 (43.0) | 49 (46.2) | 51 (42.2) | 50 (41.0) | 0.71 |
Antiplatelet | 152 (43.6) | 49 (46.2) | 50 (41.3) | 53 (43.4) | 0.76 |
Beta blocker | 155 (44.4) | 48 (45.3) | 46 (38.0) | 61 (50.0) | 0.17 |
Calcium channel blocker | 120 (34.4) | 30 (28.3) | 41 (33.9) | 49 (40.2) | 0.17 |
Statin | 174 (49.9) | 50 (47.2) | 61 (50.4) | 63 (51.6) | 0.79 |
CMR | |||||
LV end diastolic volume index, ml/m2 | 74.5 ± 24.7 | 84.3 ± 35.0 | 70.6 ± 18.1 | 70.0 ± 15.5 | < 0.001*† |
LV end systolic volume index, ml/m2 | 25.8 ± 23.3 | 35.1 ± 34.6 | 23.7 ± 17.6 | 19.6 ± 9.9 | < 0.001*†‡ |
LV ejection fraction, % | 68.8 ± 13.3 | 64.1 ± 16.8 | 68.7 ± 12.3 | 72.9 ± 8.9 | < 0.001*† |
LV mass index, g/m2 | 51.6 ± 17.6 | 60.8 ± 23.1 | 47.0 ± 11.7 | 48.2 ± 13.4 | < 0.001*†‡ |
Myocardial ischemia | 83 (23.8) | 39 (36.8) | 23 (19.0) | 21 (17.2) | 0.001*† |
Late gadolinium enhancement | 59 (16.9) | 39 (36.8) | 13 (10.7) | 7 (5.7) | < 0.001*† |