Fig. 6From: A20 (TNFAIP3) alleviates viral myocarditis through ADAR1/miR-1a-3p-dependent regulationADAR1 promotes the expression of miR-1a-3p by binding to Dicer. Notes qRT-PCR and Western blotting detected the expression of ADAR1 in the myocardium of VMC mice (A, B), and in CVB3-infected primary neonatal rat cardiomyocytes and H9c2 cells (C, D); E Co-IP assay verified the binding between ADAR1 and Dicer; qRT-PCR (F) and Western blotting (G) detected the expressions of ADAR1, miR-1a-3p and A20 in primary neonatal rat cardiomyocytes and H9c2 cells that were transfected with LV-sh-NC, LV-sh-ADAR1, LV-NC or LV-ADAR1. *P < 0.05; **P < 0.01; ***P < 0.001; VMC viral myocarditis, CVB3 Coxsackie virus B3, Co-IP co-immunoprecipitationBack to article page