Plasma metabolomic profiling of hypertrophic cardiomyopathy patients before and after surgical myectomy suggests postoperative improvement in metabolic function

Table 1 Patient summary demographics and clinical characteristics

Patient	2795	2799	2804	2815	2824	2829	2834	2841	2869	2855	2818	2875	2887	2916	5009	5038	5072	5119	Summary
Age at myectomy	37	43	55	56	73	73	58	63	52	76	63	73	65	62	35	41	55	54	Avg 57.4 ± 12.5
Female	Yes	No	Yes	Yes	Yes	Yes	No	No	Yes	Yes	Yes	Yes	No	Yes	No	No	Yes	Yes	67%
Prior AF	No	No	No	No	No	No	No	Yes	No	No	Yes	No	No	No	No	No	No	No	11%
Prior VT/VF	Yes	No	No	No	Yes	No	No	No	No	No	No	No	No	No	No	No	No	No	11%
Fam Hx SCD	Yes	No	No	No	No	No	No	No	No	No	No	No	No	No	No	No	No	No	6%
Fam Hx HCM	Yes	No	Yes	No	No	No	No	No	No	Yes	No	No	No	No	No	No	No	No	17%
Medications
Beta blocker	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	89%
Calcium channel blocker	No	No	No	Yes	No	Yes	No	No	No	No	Yes	No	No	Yes	No	No	No	No	22%
ACE or ARB	No	No	No	No	No	No	No	No	Yes	No	No	No	Yes	Yes	No	No	No	Yes	22%
Diuretic use	No	No	No	Yes	No	No	Yes	No	No	No	Yes	No	No	Yes	No	No	No	No	22%
Physiological measurement
Systolic blood pressure	135	128	110	170	105	126	142	126	148	128	122	117	140	130	130	140	128	118	Avg 130.2 ± 14.8
Diastolic blood pressure	80	82	80	70	56	78	90	78	74	78	70	70	80	70	90	70	75	70	Avg 75.6 ± 8.0
IVS thickness (mm)	23	13	15	15	17	15	15	18	14	23	17	18	17	16	15	21	17	12	Avg 16.7 ± 3.0
LVEF (%)	65	70	65	65	70	65	65	65	65	60	65	65	60	70	65	60	70	70	Avg 65.6 ± 3.4
LVOT gradient max (mm Hg)	60	60	85	90	100	150	110	100	145	150	100	100	80	64	160	100	90	100	Avg 102.4 ± 30.6
Pathogenic HCM Variant	MYBPC3	NF	NF	NF	MYBPC3	NF	NF	NF	NF	NF	NF	NF	NF	NF	NF	NF	MYH7	NF	17%

AF, atrial fibrillation; VT/VF, ventricular tachycardia or ventricular fibrillation; SCD, sudden cardiac death; HCM, hypertrophic cardiomyopathy; MR, mitral regurgitation; NF, not found; ND, not done

ISSN: 1471-2261