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Table 2 Sociodemographic, clinical and psychosocial factors in patients with confirmed and refuted SAMSa in MUSE trial

From: Clinical and psychological factors in coronary heart disease patients with statin associated muscle side-effects

  Confirmed SAMS (N = 20, 28.1%) Refuted SAMS
(N = 51, 71.8%)
p-value
Socio-demographic factors    
Age, mean (SD) 64.1 (11.0) 63.2 (8.9) 0.74
Female gender, n (%) 7 (35) 16 (31) 0.77
Low educationb, n (%) 12 (60) 33 (65) 0.71
Living alone, n (%) 4 (20) 8 (16) 0.66
Clinical factors    
Myocardial infarction, n (%) 17 (85) 43 (84) 0.94
> 1 previous coronary event, n (%) 5 (25) 21 (41) 0.20
Low Density Lipoprotein Cholesterol (mmol/L), mean (SD) 2.8 (1.2) 2.3 (0.9) 0.06
Rheumatic, inflammatory disease or arthrosis, n (%) 8 (40) 18 (35) 0.71
No ongoing statin therapy at study start, n (%) 5 (25) 3 (6) 0.02
Ezetemibe, n (%) 3 (15) 13 (26) 0.34
Previous discontinuation due to side-effects, n (%) 8 (40) 28 (55) 0.26
Psychological factors    
HADSc anxiety score, mean (SD) 4.2 (4.0) 5.4 (3.2) 0.18
HADS depression score, mean (SD) 3.3 (2.1) 4.0 (2.8) 0.31
Type D personality, SI-sumd, mean (SD) 5.6 (6.0) 7.3 (5.9) 0.29
Type D personality, NA-sume, mean (SD) 5.0 (5.1) 6.9 (4.6) 0.14
PWSQf worry scores, mean (SD) 35.8 (11.5) 39.3 (9.0) 0.18
Bergen Insomnia scale, mean (SD) 17.4 (12.1) 17.9 (11.9) 0.88
Beliefs about Medicines    
Necessity of statins, mean (SD) 14.9 (2.5) 17.5 (2.3) < 0.01
Concerns of statins, mean (SD) 14.6 (4.4) 15.8 (4.7) 0.34
  1. SD, standard deviations, aSAMS, statin-associated muscle symptoms, bLow education was defined as completion of primary or secondary school only, cHADS, Hospital anxiety and depression scale, dSI-sum, Social inhibition sumscore, eNA-sum, Negative affectivity sumscore, fPSWQ, Penn State Worry Questionnaire