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Fig. 5 | BMC Cardiovascular Disorders

Fig. 5

From: Characterization of atherosclerotic plaques in blood vessels with low oxygenated blood and blood pressure (Pulmonary trunk): role of growth differentiation factor-15 (GDF-15)

Fig. 5

Effect of GDF-15 deficiency on the morphology (apoptosis, autophagy) of atherosclerotic plaques in the pulmonary trunk (PT). Immunohistomorphometric / histochemical analyses of atherosclerotic lesions in the PT of ApoE−/− and GDF15−/−ApoE−/− mice after 20 weeks of CED. A APG5L/ATG (autophagy); B TUNEL (apoptosis); representative pictures of immuno-/histochemistry reactions for C APG5L/ATG immuno-stained cross sections and D TUNEL+. Black arrow: APG5L/ATG + or TUNEL+; L: lumen; Nc: necrotic core; TA: tunica adventitia. Data are expressed as mean + SEM; scale bar 100 µm, n = 4–5

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