Outcome | Men | Women | p value for multiplicative interaction | ICR | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Model 1† | Model 2†† | Model 1† | Model 2†† | |||||||
Rate control | Rhythm control | Rate control | Rhythm control | Rate control | Rhythm control | Rate control | Rhythm control | |||
Heart failure | ||||||||||
Events/N | 5290/65,843 | 3052/31,047 | 5290/65,843 | 3052/31,047 | 5121/75,251 | 2761/28,753 | 5121/75,251 | 2761/28,753 | < 0.0001 | 0.152 |
HR (95% CI) | 1 (ref.) | 1.20 (1.14, 1.25) | 1 (ref.) | 1.21 (1.15, 1.28) | 1 (ref.) | 1.34 (1.28, 1.40) | 1 (ref.) | 1.41 (1.34, 1.49) | ||
Stroke | ||||||||||
Events/N | 1838/66,102 | 682/31,209 | 1838/66,102 | 682/31,209 | 2829/75,465 | 961/28,899 | 2829/75,465 | 961/28,899 | 0.08 | 0.071 |
HR (95% CI) | 1 (ref.) | 0.73 (0.67, 0.80) | 1 (ref.) | 0.79 (0.72, 0.87) | 1 (ref.) | 0.81 (0.75, 0.87) | 1 (ref.) | 0.85 (0.78, 0.92) | ||
Major bleeding | ||||||||||
Events/N | 3529/66,041 | 1876/31,143 | 3529/66,041 | 1876/31,143 | 3756/75,413 | 1664/28,866 | 3756/75,413 | 1664/28,866 | 0.99 | − 0.03 |
HR (95% CI) | 1 (ref.) | 1.04 (0.98, 1.10) | 1 (ref.) | 1.07 (1.01, 1.14) | 1 (ref.) | 1.01 (0.95, 1.07) | 1 (ref.) | 1.02 (0.96, 1.09) |