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Table 2 Association of biological sex with treatment choice within 30-days after a diagnosis of atrial fibrillation among elderly participants in the MarketScan database (2007–2015)

From: Sex differences in treatment strategy and adverse outcomes among patients 75 and older with atrial fibrillation in the MarketScan database

Treatment 30-day after diagnosis

Men

Women

Any anticoagulant (vs. none)

 Events/N

37,574/135,850

36,805/139,767

 %

27.7

26.3

 

RR (95% CI)

 Model 1

1 (ref.)

1.00 (0.98, 1.01)

 Model 2††

1 (ref.)

0.94 (0.93, 0.96)

DOAC (vs. warfarin)

 Events/N

6821/37,574

6900/36,805

 %

18.2

18.7

 

RR (95% CI)

 Model 1

1 (ref.)

1.04 (1.01, 1.07)

 Model 2††

1 (ref.)

1.05 (1.01, 1.08)

Rhythm control (vs. rate)

 Events/N

17,232/60,053

15,722/67,638

 %

28.7

23.2

 

RR (95% CI)

 Model 1

1 (ref.)

0.85 (0.83, 0.86)

 Model 2††

1 (ref.)

0.94 (0.93, 0.96)

  1. RR risk ratio, CI confidence interval, DOAC direct oral anticoagulants
  2. Bolded results are statistically significant at p value of 0.05
  3. Model 1 adjusts for age
  4. ††Model 2 adjusts for age plus heart failure, hypertension, diabetes mellitus, stroke, myocardial infarction, peripheral arterial disease, chronic kidney disease, gastrointestinal bleed, liver disease, hyperlipidemia, chronic obstructive pulmonary disease, depression, dementia, intracranial bleeding, other forms of bleeding, alcohol abuse, use of lipid lowering medication, beta blockers, calcium channel blockers, angiotensin receptor blocker, angiotensin converting enzyme inhibitor, diuretics, gastrointestinal drugs, cardiac drugs, potassium supplements, anti-diabetics, anti-platelet drugs, thiazide diuretics, anti-arrhythmics, insulin, sulphonylureas, other diuretics, statins, digoxin and oral anticoagulant use (in models assessing initiation of Rhythm v. Rate control)