Table 3 [89Zr]Zr-dezamizumab biodistribution in cardiac and non-cardiac tissues/organs expressed as SUV over time (immuno-PET study; all-treated population)
Patient A | Patient B | |||||||
|---|---|---|---|---|---|---|---|---|
Session 1 | Session 2 | Session 1 | ||||||
Day 4 | Day 6 | Day 3 | Day 4 | Day 5 | Day 4 | Day 5 | Day 8 | |
Organ/tissue | SUV mean | |||||||
Liver | 12.96 | 16.94 | 4.77 | 7.56 | 8.34 | 22.65 | 25.56 | 24.80 |
Adrenal | 13.03 | 12.02 | 4.80 | 8.38 | 6.36 | 10.30 | 10.77 | 10.90 |
Spleen | 9.80 | 10.06 | 4.44 | 5.14 | 5.44 | 13.05 | 11.05 | 11.34 |
Thyroid—goiter hotspot | 4.67 | 4.24 | 1.89 | 3.69 | 3.19 | – | – | – |
Kidney | 4.08 | 3.84 | 2.70 | 3.26 | 2.89 | 5.74 | 5.13 | 4.82 |
Testes | – | – | – | – | – | 5.40 | 5.52 | 5.67 |
Aorta | 3.56 | 0.50 | 10.00 | 5.89 | 3.31 | 1.60 | 0.36 | 0.65 |
Heart | 3.30 | 1.32 | 7.09 | 4.44 | 3.39 | 1.64 | 1.13 | 0.96 |
Bone marrow | 2.45 | 2.21 | 1.86 | 1.91 | 1.41 | 3.58 | 3.17 | 3.88 |
Cardiac focal anatomical locations | SUV peak | |||||||
Blood pool left atrium | 4.03 | 0.64 | 10.29 | 5.33 | 3.55 | 1.96 | 0.55 | 0.40 |
Blood pool left ventricle | 3.88 | 0.85 | 10.12 | 4.91 | 3.11 | 1.72 | 0.51 | 0.43 |
Blood pool right ventricle | 3.98 | 0.95 | 10.39 | 5.16 | 3.50 | 2.35 | 1.05 | 1.24 |
Left ventricle wall—high uptake | 3.40 | 3.40 | 1.15 | 4.54 | 5.36 | 1.36 | 1.29 | 1.44 |
Left ventricle wall—low uptake | 2.76 | 1.84 | 3.11 | 3.65 | 3.98 | 0.72 | 0.70 | 0.76 |
Mid septum—high uptake | 3.22 | 2.88 | 4.68 | 4.20 | 4.78 | 1.45 | 1.42 | 1.52 |
Mid septum—low uptake | 3.09 | 2.23 | 3.58 | 3.57 | 3.80 | 0.82 | 0.78 | 0.61 |