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Fig. 5 | BMC Cardiovascular Disorders

Fig. 5

From: Resveratrol ameliorates myocardial fibrosis by regulating Sirt1/Smad3 deacetylation pathway in rat model with dilated cardiomyopathy

Fig. 5

AC-Smad3, not p-Smad3 was mainly down regulated by Sirt1. The interaction between Sirt1 and Smad3 was detected by immunoprecipitation. a One representative image of immunoprecipitation. bd Statistical analysis for the relative protein levels of Sirt1, AC-Smad3 and p-Smad3. AC-Smad3, Acetylation Smad3; p-Smad3, phospho-Smad3; Sirt1, Silence information regulator1; DCM, dilated cardiomyopathy; RSV-L, low dose of RSV (10 mg/kg/d); RSV-H, high dose of RSV (50 mg/kg/d); ***, P < 0.0001; **, P < 0.001; ns, P > 0.05

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