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Table 4 Cox regression analysis for SCA or VA in patients with MVP

From: Usefulness of cardiac magnetic resonance images for prediction of sudden cardiac arrest in patients with mitral valve prolapse: a multicenter retrospective cohort study

 

Univariable

Multivariable

(Model 1)

Multivariable

(Model 2)

Multivariable

(Model 3)

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Male sex

6.28 (0.75–52.28)

0.089

      

Age (year)

0.96 (0.91–10.00)

0.050

1.07 (0.98–1.17)

0.150

1.10 (0.99–1.23)

0.076

1.12 (0.99–1.25)

0.063

BMI (kg/m2)

1.14 (0.98–1.33)

0.089

      

Diabetes mellitus

1.81 (0.22–15.1)

0.584

      

Hypertension

0.43 (0.05–3.54)

0.429

      

Dyslipidemia

0.04 (0–1453.85)

0.550

      

ECG

PR interval (ms)

1.01 (0.99–1.03)

0.199

      

QRS duration (ms)

1.05 (1.02–1.08)

0.003

1.08 (1.01–1.14)

0.024

1.06 (1.01–1.12)

0.020

1.07 (1.01–1.14)

0.023

QTc (ms)

0.99 (0.97–1.02)

0.645

      

Atrial fibrillation

0.85 (0.16–4.38)

0.845

      

BBB

2.00 (0.21–19.45)

0.550

      

Inverted T wave in inferior leads

2.64 (0.51–13.67)

0.248

      

Echocardiography

MR grade

 Not severe

[Ref]

[Ref]

      

 Severe

0.68 (0.15–3.09)

0.618

      

Involved leaflet

 One leaflet

[Ref]

[Ref]

      

 Both leaflet

2.31 (0.27–19.89)

0.445

      

 Ruptured chordae tendinae

0.36 (0.04–2.99)

0.342

      

 RVSP (mmHg)

0.85 (0.74–0.97)

0.015

0.89 (0.77–1.03)

0.113

0.84 (0.68–1.05)

0.123

0.86 (0.69–1.06)

0.148

CMR

LVEF

0.99 (0.94–1.05)

0.748

      

LVEDV index

0.99 (0.98–1.01)

0.523

      

LVESV index

1.00 (0.98–1.02)

0.806

      

RVEF

1.02 (0.96–1.08)

0.503

      

RVEDV index

1.00 (0.98–1.02)

0.769

      

RVESV index

0.99 (0.96–1.02)

0.601

      

LA volume index

0.97 (0.94–1.01)

0.112

      

Prolapse distance

1.01 (0.91–1.11)

0.916

      

MAD*

5.64 (1.23–25.81)

0.026

      

Systolic curling motion*

11.17 (2.23–55.89)

0.003

13.04 (1.37–124.45)

0.026

55.23 (2.18–1402.07)

0.015

110.9 (2.93–4191.92)

0.011

Presence of LGE†

14.48 (3.19–65.68)

0.001

19.8 (2.65–148.15)

0.004

–

–

–

–

LGE volume (g)†

1.06 (1.03–1.10)

 < 0.001

–

–

1.08 (1.02–1.14)

0.006

–

–

LGE proportion (%)†

1.22 (1.10–1.34)

 < 0.001

–

–

–

–

1.32 (1.08–1.60)

0.006

  1. BBB Bundle branch block, BMI body mass index, calculated as weight in kilograms divided by the square of height in meters, CMR cardiac magnetic resonance, ECG electrocardiography, HR hazard ratio, LGE late gadolinium enhancement, LVEDV left ventricular end diastolic volume, LVEF left ventricular ejection fraction, LVESV left ventricular end systolic volume, MAD mitral annular disjunction, MR mitral regurgitation, MVP mitral valve prolapse, Ref reference, RVEDV right ventricular end diastolic volume, RVEF right ventricular ejection fraction, RVESV right ventricular end systolic volume, RVSP right ventricular systolic pressure, SCA sudden cardiac arrest, VA ventricular arrhythmia
  2. *Only systolic curling motion was used on the multivariable Cox regression analysis due to multicollinearity with MAD
  3. †These three variables were analyzed separately in Model 1, Model 2, and Model 3 due to milticollinearity
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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