Biomarker | Univariate model | Multivariable model |
---|
HR [95%CI] | Pfdr | HR [95%CI] | Pfdr |
---|
Total NT-proBNP | 1.54 (1.30–1.83) | 1.9 × 10–6 | 1.57 (1.29–1.90) | 1.2 × 10–5 |
NT-proBNP | 1.49 (1.31–1.70) | 5.6 × 10–9 | 1.57 (1.34–1.84) | 1.2 × 10–6 |
Ang2 | 1.31 (1.08–1.59) | 0.007 | 1.34 (1.04–1.73) | 0.029 |
BMP10 | 1.38 (1.10–1.74) | 0.007 | 1.25 (0.96–1.63) | 0.097 |
- The prediction of cardiovascular hospitalization was assessed by Cox proportional hazards regression. Data shown as hazard ratio HR for an increment of 1 SD of baseline biomarker concentration. The multivariable model was adjusted for systolic blood pressure, history of hypertension, peripheral artery disease and smoking. P-value was corrected for multiple testing by means of FDR-correction. HR, hazard ratio; NT-proBNP, N-terminal pro-B type natriuretic peptide; Ang2, angiopoietin 2; BMP10, bone morphogenic protein-10