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Table 1 Biomarker concentrations at each study visit and lower limit of quantification and detection

From: Total NT-proBNP, a novel biomarker related to recurrent atrial fibrillation

Biomarker

Visit

n

Mean

Std Dev

Median

Q1

Q3

Min

Max

LoQ

LoD

Total NT proBNP *

pg/mL

BL

376

1727

1712

1230

667

2011

75

12,700

8.3 pg/mL

6.52 pg/mL

6 M

321

1494

1611

985

507

1959

34

12,626

12 M

323

1672

1825

1008

564

2112

62

11,992

NT-proBNP (pg/mL)

BL

382

344.6

496.3

191.0

95.0

367.0

5.0

4347

50

pg/mL#

10

pg/mL##

6 M

325

278.6

414.5

136.0

66.0

324.0

5.0

3906

12 M

331

328.0

555.9

149.0

63.0

350.0

5.0

6345

Ang2 *

ng/mL

BL

379

3.44

1.95

2.91

2.21

3.99

0.73

15.04

0.058 ng/mL

0.028 ng/mL

6 M

324

2.85

1.34

2.49

2.01

3.19

1.01

10.14

12 M

329

2.88

1.31

2.56

2.02

3.28

1.16

10.09

BMP10 *

ng/mL

BL

375

2.09

0.52

2.02

1.75

2.33

1.14

5.04

0.009 ng/mL

0.003

ng/mL

6 M

321

2.05

0.47

2.01

1.75

2.28

1.16

4.76

12 M

327

2.09

0.50

2.00

1.74

2.34

1.15

4.54

DKK3 *

ng/mL

BL

377

59.87

15.37

57.5

49.3

68.7

27.1

142.6

0.025 ng/mL

0.003

ng/mL

6 M

321

57.83

14.42

55.8

48.2

64.0

28.7

118.7

12 M

324

59.51

16.47

57.5

48.6

66.2

26.8

136.9

ESM1 *

ng/mL

BL

377

2.23

1.01

2.02

1.65

2.55

0.87

9.17

 < 0.003 ng/mL

0.001 ng/mL

6 M

321

2.04

0.65

1.94

1.62

2.33

0.97

5.65

12 M

324

2.13

0.70

1.99

1.64

2.47

0.85

5.68

FABP3 *

ng/mL

BL

375

30.98

10.96

29.2

24.2

35.3

12.1

105.3

1.0 ng/mL

n.a

6 M

321

33.17

11.17

31.2

25.7

38.8

11.6

86.7

12 M

327

34.80

12.13

33.1

26.2

40.1

15.0

91.4

FGF23 *

pg/mL

BL

374

0.14

0.10

0.11

0.09

0.15

0.01

0.87

0.004 ng/mL

n.a

6 M

321

0.14

0.09

0.11

0.09

0.15

0.01

0.92

12 M

322

0.14

0.10

0.12

0.09

0.15

0.03

0.94

GDF15

pg/mL

BL

375

1272

793

1053

745

1523

235

7059

 ≤ 400 pg/mL

 ≤ 400 pg/mL

6 M

321

1344

1136

1080

794

1518

317

12,471

12 M

327

1355

965

1140

808

1555

369

9783

IGFBP7 *

ng/mL

BL

379

178

44

172

152

194

97

685

0.4 ng/mL

0.01 ng/mL

6 M

324

179

48

170

154

191

80

705

12 M

329

184

49

174

157

199

91

701

MYBPC3 *

ng/mL

BL

373

5.63

6.33

3.69

2.29

6.35

0.34

48.48

2.1

pg/mL

0.458 pg/mL

6 M

321

4.86

6.31

3.18

1.98

5.42

0.29

66.73

12 M

327

4.98

5.91

3.10

1.91

5.95

0

47.05

  1. NT-proBNP—N-terminal pro-B type natriuretic peptide; Ang2—angiopoietin 2; BMP10—bone morphogenic protein-10; DKK3—Dickkopf-related protein-3; ESM1—endothelial cell specific molecule 1; FABP3—fatty acid-binding protein 3; FGF23—fibroblast growth factor 23; GDF15—growth differentiation factor-15; IGFBP7—insulin-like growth factor-binding protein-7; MyBPC3—myosin binding protein C3. Reference value: NT-proBNP, 125 pg/mL; GDF15, > 1500 ng/mL (arbitrary value suitable for GISSI-AF population). * Research Use Only (RUO) assays without full in vitro diagnostic (IVD) documentation, reference value not available. LoQ, lower limit of quantification; LoD, lower limit of detection. #, LoQ – 20% CV at ≤ 50 pg/mL C; ##, 10 pg/mL (specification) on cobas e 411, cobas e 601, cobas e 602;
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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