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Table 1 Characteristics of the SNPs associated with plasma levels of n-3 polyunsaturated fatty acids (PUFAs)

From: Effect of n-3 polyunsaturated fatty acids on ischemic heart disease and cardiometabolic risk factors: a two-sample Mendelian randomization study

n-3 PUFA

Nearest gene

SNP

Chr. position

EA/NEA

EAF

Effect

SE

p-value

VE (%)

F

ALA

FEN1

rs412334

11:61316837

t/c

0.16

− 0.0118

0.0016

9.72E−14

0.342

30

C11orf9

rs198464

11:61278197

a/g

0.50

− 0.0057

0.0009

2.48 E−11

0.148

13

C11orf10

rs740006

11:61314444

t/c

0.90

0.0163

0.0025

1.32 E−10

0.440

39

C11orf9

rs17762402

11:61309777

a/g

0.07

− 0.0186

0.0029

1.56 E−10

0.411

37

DHA

ELOVL2

rs2236212

6:10995015

c/g

0.41

− 0.1132

0.0141

1.26 E−15

0.646

58

DPA

ELOVL2

rs3734398

6:10982973

t/c

0.57

− 0.0404

0.0029

9.61 E−44

2.667

243

FEN1

rs412334

11:61560261

t/c

0.16

0.0554

0.0052

1.40 E−26

2.750

251

C11orf10

rs740006

11:61557868

t/c

0.9

− 0.0764

0.0079

4.50 E−22

3.502

322

FADS3

rs7394871

11:61652514

a/c

0.05

− 0.0637

0.0078

3.56 E−16

1.285

115

FADS2

rs498793

11:61624705

t/c

0.43

0.0307

0.0038

5.84 E−16

1.540

139

SYCP2L

rs12199131

6:10932569

a/g

0.26

0.0267

0.0033

7.69 E−16

0.914

82

RAB3IL1

rs174472

11:61671956

a/g

0.58

0.0274

0.0037

5.74 E−14

1.219

109

C11orf9

rs17762402

11:61553201

a/g

0.06

0.0805

0.0109

1.42 E−13

2.437

221

SYCP2L

rs6928281

6:10908917

t/g

0.72

0.0226

0.0032

8.04 E−13

0.686

61

C11orf9

rs198464

11:61521621

a/g

0.49

0.0191

0.0028

7.47 E−12

0.608

54

FADS2

rs17156442

11:61614023

t/c

0.05

− 0.0513

0.0077

2.09 E−11

0.833

74

BEST1

rs1109748

11:61722645

a/c

0.07

− 0.0400

0.0068

5.09 E−09

0.694

62

ELOVL2

rs6936315

6:11035972

t/c

0.84

0.0244

0.0043

1.34 E−08

0.533

48

FTH1

rs10792320

11:61746291

a/c

0.65

0.0160

0.0030

8.49 E−08

0.388

35

BEST1

rs2727266

11:61704334

a/g

0.93

0.0308

0.0058

8.86 E−08

0.412

37

EPA

FADS3

rs7394871

11:61652514

a/c

0.05

− 0.0912

0.0128

1.13 E−12

0.494

44

ELOVL2

rs3798713

6:11008622

c/g

0.42

0.0350

0.0050

1.93 E−12

0.373

33

BEST1

rs1109748

11:61722645

a/c

0.07

− 0.0535

0.0092

5.46 E−09

0.233

21

FEN1

rs412334

11:61560261

t/c

0.16

0.0440

0.0081

4.59 E−08

0.325

29

FADS2

rs498793

11:61624705

t/c

0.43

0.0351

0.0064

5.11 E−08

0.377

34

MAT2B

rs1145652

5:164764087

a/g

0.87

0.0356

0.0066

8.39 E−08

0.179

16

  1. ALA α-linolenic acid, Chr. chromosome, DHA docosahexaenoic acid, DPA docosapentaenoic acid, EA effect allele, EAF effect allele frequency, EPA eicosapentaenoic acid, F F-statistic, NEA non-effect allele, PUFAs polyunsaturated fatty acids, SE standard error, SNP single nucleotide polymorphism, VE variation explained
  2. VE (%) = (2 × Effect2 × EAF × (1 − EAF)/var (n-3 PUFAs)) × 100, var (n-3 PUFA) is the variance of n-3 PUFA and was deduced based on literature data (PMID: 27490808). F-statistic is a measure of the strength of the genetic instrument and is calculated as follows: F = (R2 × (n − 1 − k))/((1 − R2) × k), where R2 = VE (%), n = sample size, k = number of instrumental variables