2004–2006 n = 4847 | 2007–2009 n = 6104 | 2010–2012 n = 5547 | 2013–2016 n = 7042 | |||||
---|---|---|---|---|---|---|---|---|
Mean age, years (IQR) | 66 (58–74) | 67 (59–74) | 67 (59–75) | 68 (59–75) | ||||
Male sex | 3554 | 73.3 | 4279 | 70.1 | 3732 | 67.3 | 4843 | 68.8 |
Family history | 2290 | 47.2 | 2892 | 47.4 | 2687 | 48.4 | 3218 | 45.7 |
Active smoker | 1293 | 26.7 | 1401 | 23.0 | 1275 | 23.0 | 1467 | 20.8 |
Comorbidity | ||||||||
Hypertension | 2875 | 59.3 | 3949 | 64.7 | 3736 | 67.4 | 4488 | 63.7 |
Previous ischemic stroke | 42 | 0.9 | 88 | 1.4 | 113 | 2.0 | 158 | 2.2 |
Atrial fibrillation | 391 | 8.1 | 499 | 8.2 | 474 | 8.5 | 643 | 9.1 |
Peripheral artery disease | 260 | 5.4 | 361 | 5.9 | 363 | 6.5 | 427 | 6.1 |
Heart failure | 390 | 8.0 | 434 | 7.1 | 357 | 6.4 | 358 | 5.1 |
Renal disease | 61 | 1.3 | 93 | 1.5 | 91 | 1.6 | 171 | 2.4 |
Mean eGFR, mL/min (IQR) | 81 (66–96) | 86 (70–102) | 89 (74–104) | 89 (74–104) | ||||
Median BMI, kg/m2 (IQR) | 27 (24–29) | 27 (24–30) | 27 (24–29) | 27 (24–29) | ||||
Modified Charlson Comorbidity Index score | ||||||||
0 points | 3931 | 81.1 | 4568 | 74.8 | 3917 | 70.6 | 4799 | 68.1 |
1 point | 607 | 12.5 | 929 | 15.2 | 893 | 16.1 | 1162 | 16.5 |
2 point | 222 | 4.6 | 411 | 6.7 | 488 | 8.8 | 696 | 9.9 |
≥ 3 points | 87 | 1.8 | 196 | 3.2 | 249 | 4.5 | 385 | 5.5 |
CAD extent | ||||||||
1 VD | 1764 | 36.4 | 2321 | 38.0 | 2049 | 36.9 | 2661 | 37.8 |
2 VD | 1236 | 25.5 | 1437 | 23.5 | 1141 | 20.6 | 1391 | 19.8 |
3 VD | 1530 | 31.6 | 1386 | 22.7 | 1029 | 18.6 | 1132 | 16.1 |
Diffuse VD | 317 | 6.5 | 960 | 15.7 | 1328 | 23.9 | 1858 | 26.4 |
Medication | ||||||||
Statin | ||||||||
Before | 3141 | 64.8 | 4136 | 67.8 | 3667 | 66.1 | 4490 | 63.8 |
After | 4347 | 91.4 | 5453 | 90.9 | 4879 | 89.1 | 6195 | 89.0 |
Aspirin | ||||||||
Before | 3795 | 78.3 | 4621 | 75.7 | 4009 | 72.3 | 4717 | 67.0 |
After | 4105 | 86.3 | 5067 | 84.5 | 4555 | 83.2 | 5500 | 79.0 |
ADP-inhibitor | ||||||||
Before | 148 | 3.1 | 145 | 2.4 | 215 | 3.9 | 487 | 6.9 |
After | 2540 | 53.4 | 2962 | 49.4 | 2535 | 46.3 | 3240 | 46.5 |
Vitamin K antagonists | ||||||||
Before | 354 | 7.3 | 427 | 7.0 | 360 | 6.5 | 376 | 5.3 |
After | 519 | 10.7 | 535 | 8.9 | 471 | 8.6 | 484 | 7.0 |
Non-vitamin K antagonists | ||||||||
Before | 0 | 0.0 | < 5 | 0.0 | 38 | 0.7 | 268 | 3.8 |
After | 0 | 0.0 | < 5 | 0.0 | 61 | 1.1 | 347 | 5.0 |
Beta-blocker | ||||||||
Before | 3348 | 69.1 | 3674 | 60.2 | 2868 | 51.7 | 2756 | 39.1 |
After | 3582 | 75.3 | 4219 | 70.3 | 3498 | 63.9 | 3707 | 53.2 |
ACE inhibitor | ||||||||
Before | 1260 | 26.0 | 1643 | 26.9 | 1587 | 28.6 | 1590 | 22.6 |
After | 1534 | 32.3 | 1947 | 32.5 | 1749 | 31.9 | 1694 | 24.3 |
ARB | ||||||||
Before | 667 | 13.8 | 976 | 16.0 | 978 | 17.6 | 1479 | 21.0 |
After | 731 | 15.4 | 1041 | 17.4 | 1057 | 19.3 | 1564 | 22.5 |
Thiazides | ||||||||
Before | 891 | 18.4 | 1077 | 17.6 | 954 | 17.2 | 917 | 13.0 |
After | 964 | 20.3 | 1111 | 18.5 | 930 | 17.0 | 914 | 13.1 |
Calcium channel blocker | ||||||||
Before | 1601 | 33.0 | 1958 | 32.1 | 1741 | 31.4 | 1982 | 28.1 |
After | 1777 | 37.4 | 2408 | 40.1 | 2211 | 40.4 | 2550 | 36.6 |