Transition from metabolically healthy to unhealth status associated with risk of carotid artery plaque in Chinese adults

Table 2 Risk of developing different metabolic abnormalities during follow-up, according to baseline body weight status in 9836 Chinese adults who were metabolically healthy

Outcome	Metabolically healthy normal weight	Metabolically healthy overweight
Outcome	(BMI < 24.0 kg/m²)	(BMI ≥ 24.0 kg/m²)
HBP
Number of participants	7512	2324
Incident case	2400	1177
Model 1	Ref (1.0)	1.50 (1.4, 1.61)
Model 2	Ref (1.0)	1.49 (1.39, 1.6)
Model 3	Ref (1.0)	1.23 (1.14, 1.33)
IGR
Number of participants	7512	2324
Incident case	1394	594
Model 1	Ref (1.0)	1.36 (1.24, 1.51)
Model 2	Ref (1.0)	1.31 (1.2, 1.49)
Model 3	Ref (1.0)	1.15 (1.04, 1.28)
High TC
Number of Participants	7512	2,324
Incident case	836	266
Model 1	Ref (1.0)	1.08 (0.94, 1.25)
Model 2	Ref (1.0)	1.07 (0.93, 1.24)
Model 3	Ref (1.0)	1.03 (0.89, 1.19)
High TG
Number of participants	7512	2324
Incident case	908	595
Model 1	Ref (1.0)	1.79 (1.6, 1.99)
Model 2	Ref (1.0)	1.77 (1.59, 1.97)
Model 3	Ref (1.0)	1.12 (1.001, 1.25)
High LDL-C
Number of participants	7512	2324
Incident case	1264	550
Model 1	Ref (1.0)	1.31 (1.18, 1.45)
Model 2	Ref (1.0)	1.3 (1.17, 1.44)
Model 3	Ref (1.0)	0.99 (0.89, 1.11)
Low HDL-C
Number of participants	7512	2324
Incident case	371	238
Model 1	Ref (1.0)	1.78 (1.5, 2.1)
Model 2	Ref (1.0)	1.75 (1.48, 2.08)
Model 3	Ref (1.0)	0.99 (0.83, 1.18)

If the number "1" is not included in the confidence interval, it means significant
Model 1: adjusting for age and sex. Model 2: adjusting for variables in model 1 and estimated glomerular filtration rate (ml/min/1.73 m²), and high sensitivity C-reactive protein (mg/L). Model 3: adjusting for variables in model 2 and systolic blood pressure (mmHg), diastolic blood pressure (mmHg), FBG (mmol/L), HbA1c (%), TC (mmol/L), TG (mmol/L), LDL-C (mmol/L), HDL-C (mmol/L)
HBP, high blood pressure; FBG, fasting blood glucose; HbA1c, glycated hemoglobin A1c; IGR, impaired glucose regulation; TC, total cholesterol; TG, total triglycerides; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol
Definition: Metabolically healthy was defined as participants without history of high blood pressure, diabetes mellitus, cardiovascular disease, dyslipidemia, and cancer but with normal blood pressure, FBG, HbA1c, TC, TG, LDL-C, and HDL-C. Criteria for metabolic abnormality: HBP (systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 80 mmHg); IGR (FBG ≥ 5.6 mmol/L or HbA1c ≥ 5.7%); high TC, ≥ 5.72 mmol/L; high TG, ≥ 1.7 mmol/L; high LDL-C, ≥ 3.4 mmol/L; low HDL-C, < 0.9 mmol/L in men and < 1.0 mmol/L in women

ISSN: 1471-2261