Table 3 Users of FQ and incidence of AAD
From: Current progress of fluoroquinolones-increased risk of aortic aneurysm and dissection
OR (95% CI) | Outcome | Comorbid illnesses | Patient characteristic | References |
|---|---|---|---|---|
HR = 2.57; 95% CI 1.36–4.86 | AAD | Pneumonia | [48] | |
OR = 1.01; 95% CI 0.82–1.24 | FQ didn’t increase the risk of AAD | Combined amoxicillin-clavulanate or ampicillin-sulbactam | [52] | |
OR = 0.88; 95% CI 0.70–1.11 | FQ didn’t increase the risk of AAD | Combined with extended-spectrum cephalosporins | [52] | |
Adjusted HR = 2.24; 95% CI 2.02–2.49 | AA | Older adults turning 65 years | [40] | |
HR = 1.66; 95% CI 1.12–2.46 | AAD | Aged 50 years or older | [9] | |
RR = 1.72; 95% CI 1.37–2.16 | AAD | Older than 70 years | [1] | |
HR = 1.18; 95% CI 1.09–1.28 | AA | Aged 35 years or older (35–49 years) | [41] | |
HR = 1.24; 95% CI 1.19–1.28 | AA | Aged 35 years or older (50–64 years) | [41] | |
RR = 1.83; 95% CI 1.27–2.64 | AAD | Female patients | [1] | |
RR = 1.87; 95%CI 1.24–2.51 | AAD | Female patients | [33] | |
OR = 0.92; 95% CI 0.46–1.86 | Intracranial aneurysm or dissection | [52] | ||
Adjusted HR = 1.61; 95% CI 1.50–1.73 | All-cause death | AA or AD | [49] | |
Adjusted HR = 1.80; 95% CI 1.50–2.15 | Aortic death | AA or AD | [49] |