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Table 2 Laboratory, echocardiographic and electrocardiographic characteristics in patients with AL-CA in the present study

From: A real-world study on diagnosis and prognosis of light-chain cardiac amyloidosis in Southern China

 

Normal range

AL-CA (n = 170)

Laboratory results

Hemoglobin, g/L

115–150

113.6 (22.7)

White blood cell,10^9/L

3.5–9.5

6.6 (3.0)

Platelets, 109/L

125–350

191.4 (90.7)

Potassium, mmol/L

3.5–5.3

4.1 (0.5)

Calcium, mmol/L

2.11–2.52

2.1 (0.2)

ALT, u/L

7.0–40

19.6 (13.4–28.3)

AST, u/L

13.0–35.0

27.5 (20.3–36.3)

Albumin, g/L

40.0–55.0

29.9 (6.8)

eGFR, mL/(min × 1.73m2)

90–120

60.6 (31.4)

Uric acid, umol/L

155–357

455.5 (168.5)

24-h urine protein ≥ 1.0 g, n%

90 (53.0%)

Cardiac troponin T, pg/ml

0–14

84.8 (36.4–158.8)

CK-MB, u/L

0–24

14.6 (10.2–18.9)

NT-proBNP, pg/mL

100–300

6139.4 (2957.7–11,754.0)

LDH, U/L

120–250

268.6 (216.8–331.5)

CRP, mg/L

0–8

22.6 (39.0)

TC, mmol/L

2.9–5.2

4.1 (2.1)

LDL-c, mmol/L

< 3.12

2.6 (1.4)

D-Dimer, ug/mL

0–0.55

1.7 (1.8)

Echocardiographic findings

LVEDd, mm

Male: ≤ 55, Female ≤ 50

44.0 (7.1)

RVEDd, mm

 ≤ 35

32.5 (4.9)

LAESd, mm

Male: ≤ 35, Female ≤ 30

41.0 (7.3)

RAESd, mm

≤ 30

38.4 (8.5)

IVS, mm

6–11

14.1 (3.6)

LVPW, mm

6–11

13.7 (3.3)

LVEF, (%)

> 50%

52.9 (10.0)

ECG findings

Atrial fibrillation, n%

(164) 29 (17.7%)

AV block grade I or greater, n%

(164) 23 (14.0%)

Low voltage, n%

(163) 93 (57.1%)

Pseudo necrosis, n%

(163) 6 (3.7%)

PRWP, n%

(163) 138 (84.7%)

PR interval, ms

120–200

(133) 173.8 (40.8)

Corrected QT interval, ms

320–440

(163) 471.6 (36.7)

QRS duration, ms

60–110

(163) 101.6 (38.0)

Ventricular rate, n/min

60–100

(164) 81.9 (19.6)

  1. Data are (N) Mean (SD) or (N) n (%), Median (Q3–Q1), where N is the total number of patients with available data
  2. ALT: Alanine transaminase; AST: aspartate aminotransferase; eGFR: estimated glomerular filtration rate; CK-MB: creatine kinase myocardial isoenzyme; CRP: C-reactive protein; LDL-C: low density lipoprotein-cholesterol; TC: total cholesterol; LDH: lactate dehydrogenase; NT-proBNP: N-terminal pro–B-type natriuretic peptide; LVEDd: left ventricular end diastolic diameter; RVEDd: right ventricular end diastolic diameter; LAESd: left atrium end systolic diameter; RAEDd: right atrium end systolic diameter; IVS: interventricular septum; LVPW: left ventricular posterior wall; LVEF: left ventricular ejection fraction; PRWP: poor R-wave progression