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Table 1 Baseline characteristics are shown in the cohort, and in patients with NT-proBNP measured, separated by treatment group

From: The role of brain natriuretic peptide in atrial fibrillation: a substudy of the Substrate Modification with Aggressive Blood Pressure Control for Atrial Fibrillation (SMAC-AF) trial

Variable:

Overall

(n = 173)

Standard group (n = 75)

Aggressive group (n = 78)

NT-proBNP ≥ 280*

(n = 24)

NT-proBNP < 280

(n = 51)

p value

NT-proBNP ≥ 280

(n = 25)

NT-proBNP < 280

(n = 53)

p value

Age (years, mean ± SD)

59.7 ± 8.7

62.7 ± 6.8

57.5 ± 9.9

0.02

62.2 ± 7.4

58.7 ± 8.8

0.09

Women n (%)

45 (26.0)

9 (37.5)

12 (23.5)

0.21

10 (40)

9 (17)

0.03

Type of AF n (%):

   

0.09

  

0.06

Persistent

74 (42.8)

10 (41.7)

32 (63)

 

11 (44)

35 (66)

 

Paroxysmal

99 (57.2)

14 (58.3)

19 (37.3)

 

14 (56)

18 (34)

 

AF duration (months, mean ± SD)

57.2 ± 71.5

42.2 ± 35.6

65.5 ± 79.8

0.12

67.3 ± 99.8

51.1 ± 58.7

0.52

Systolic Blood Pressure (mmHg, mean ± SD)

142.6 ± 12.0

144.0 ± 16.6

141.5 ± 11.0

0.50

145.5 ± 11.8

141.3 ± 10.7

0.13

Hypertension n (%)

130 (75.0)

20 (83.3)

36 (70.6)

0.24

18 (72.0)

42 (79.3)

0.50

Diabetes n (%)

22 (12.7)

2 (8.3)

7 (13.7)

0.49

3 (12)

8 (15.1)

0.71

CHADS2 n (%):

   

0.61

  

0.73

0

39 (22.5)

3 (12.5)

13 (25.5)

 

7 (28)

11 (20.8)

 

1

108 (62.4)

18 (75.0)

31 (60.8)

 

13 (52)

33 (62.3)

 

2

18 (10.4)

2 (8.3)

5 (9.8)

 

3 (12)

7 (13.2)

 

 > 2

8 (4.6)

1 (4.2)

2 (3.9)

 

2 (8)

2 (3.8)

 

LVEF (%, mean ± SD)

58.6 ± 8.2

58.3 ± 9.4

60.1 ± 6.1

0.43

55.9 ± 12.1

59.7 ± 7.6

0.19

  1. Characteristics are compared between those with NT-proBNP ≥ 280 pg/mL and < 280 pg/mL, within each treatment group. The aggressive cohort had a target blood pressure of < 120/80 mmHg, and the standard cohort had a target of < 140/90 mmHg
  2. AF, atrial fibrillation; SBP, systolic blood pressure; LVEF, left ventricular ejection fraction
  3. *pg/mL