Individual and combined association analysis of famine exposure and serum uric acid with hypertension in the mid-aged and older adult: a population-based cross-sectional study

Table 5 Combined associations of SUA levels and famine exposure with prevalence of hypertension (N = 9368)

Famine exposure	Prevalence of hypertension odds ratio (95%CI)
	Model one^a		Model two^b		Model three^c		Model four^d
	SUA levels		SUA levels		SUA levels		SUA levels
Male	Normal	High	Normal	High	Normal	High	Normal	High
No-exposed	1.00 (reference)	1.81 (0.79, 4.14)	1.00 (reference)	1.79 (0.78, 4.12)	1.00 (reference)	1.76 (0.76, 4.06)	1.00 (reference)	1.65 (0.7, 3.88)
Fetal exposed	1.29 (0.95, 1.75)	2.66 (1.29, 5.49)	1.30 (0.95, 1.76)	2.75 (1.33, 5.68)	1.28 (0.94, 1.75)	2.69 (1.30, 5.58)	1.35 (0.99, 1.84)	2.22 (1.05, 4.7)
Childhood-exposed	1.39 (1.09, 1.77)	3.32 (2.09, 5.25)	1.39 (1.09, 1.78)	3.26 (2.06, 5.18)	1.38 (1.08, 1.77)	3.29 (2.07, 5.23)	1.51 (1.17, 1.93)	3.35 (2.1, 5.36)
Adolescence/adult-exposed	2.05 (1.61, 2.61)	3.26 (2.18, 4.87)	2.00 (1.57, 2.56)	3.17 (2.12, 4.75)	2.00 (1.57, 2.57)	3.17 (2.11, 4.75)	2.40 (1.86, 3.09)	3.56 (2.36, 5.38)
P for trend	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
P-interaction	< 0.001		< 0.001		< 0.001		< 0.001

Female	Normal	High	Normal	High	Normal	High	Normal	High
No-exposed	1.00 (reference)	2.07 (0.77, 5.61)	1.00 (reference)	2.07 (0.76, 5.62)	1.00 (reference)	1.98 (0.73, 5.38)	1.00 (reference)	1.86 (0.68, 5.08)
Fetal exposed	1.18 (0.91, 1.52)	2.23 (0.88, 5.69)	1.16 (0.90, 1.51)	2.23 (0.87, 5.70)	1.17 (0.90, 1.52)	2.18 (0.85, 5.59)	1.17 (0.9, 1.52)	1.88 (0.72, 4.91)
Childhood-exposed	1.63 (1.33, 2.00)	3.77 (2.37, 5.98)	1.50 (1.22, 1.85)	3.41 (2.14, 5.43)	1.52 (1.24, 1.87)	3.50 (2.19, 5.58)	1.62 (1.31, 1.99)	3.09 (1.91, 4.98)
Adolescence/adult-exposed	3.55 (2.89, 4.35)	5.94 (3.92, 9.01)	3.01 (2.43, 3.74)	4.99 (3.27, 7.62)	3.07 (2.47, 3.81)	5.12 (3.35, 7.82)	3.49 (2.8, 4.36)	5.41 (3.52, 8.34)
P for trend	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
P-interaction	< 0.001		< 0.001		< 0.001		< 0.001

Total	Normal	High	Normal	High	Normal	High	Normal	High
No-exposed	1.00 (reference)	1.96 (1.04, 3.71)	1.00 (reference)	1.94 (1.03, 3.67)	1.00 (reference)	1.93 (1.02, 3.65)	1.00 (reference)	1.80 (0.95, 3.45)
Fetal exposed	1.23 (1.01, 1.5)	2.58 (1.46, 4.55)	1.23 (1.01, 1.50)	2.66 (1.50, 4.69)	1.23 (1.01, 1.50)	2.69 (1.52, 4.75)	1.25 (1.03, 1.53)	2.23 (1.24, 4.01)
Childhood-exposed	1.53 (1.31, 1.79)	3.59 (2.60, 4.97)	1.47 (1.26, 1.72)	3.37 (2.43, 4.67)	1.49 (1.27, 1.74)	3.43 (2.47, 4.75)	1.59 (1.36, 1.87)	3.25 (2.33, 4.53)
Adolescence/adult-exposed	2.74 (2.35, 3.2)	4.37 (3.28, 5.81)	2.47 (2.11, 2.90)	3.94 (2.96, 5.26)	2.49 (2.12, 2.93)	3.99 (2.99, 5.32)	2.90 (2.47, 3.42)	4.34 (3.24, 5.81)
P for trend	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
P-interaction	< 0.001		< 0.001		< 0.001		< 0.001

BMI, body mass index; CI, confidence interval; OR, odds ratio; SUA, serum uric acid; SBP, systolic blood pressure
(1) In model one: ^aUnadjusted; age-adjusted by design
(2) In model two: ^bAdjusted for age, education, marital status, living place
(3) In model three: ^cAdjusted for age, education, marital status, living place, smoking status, alcohol consumption status, eating habit, social and leisure activities, experience of a traumatic event, taking physical activity or exercise;
(4) In model four: ^dAdjusted for age, education, marital status, living place, smoking status, alcohol consumption status, eating habit, social and leisure activities, experience of a traumatic event, taking physical activity or exercise, and BMI

ISSN: 1471-2261