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Table 5 Age stratified incidence rates and hazard ratios for emergency department visit or hospitalization for acute coronary syndrome or stroke and for any cardiovascular event among patients with medical cannabis authorisation and non-authorized controls

From: Medical cannabis authorization and the risk of cardiovascular events: a longitudinal cohort study

  

Acute coronary syndrome or stroke

Any cardiovascular event

Age strata

Exposure group

Number of events

Total Person-years

Incidence rate per 1000 persons-years (95% CI)

Adjusted Hazard ratio (95% CI)*

Number of events

Total Person-years

Incidence rate per 1000 persons-years (95% CI)

Adjusted Hazard ratio (95% CI)*

Age dichotomized

         

 ≤ 40 years

Authorized to use cannabis

6

4607.47

1.30 (0.58 -2.90)

1.48 (0.32–6.96)

47

4583.87

10.25 (7.72–13.63)

1.34 (0.75–2.42)

Controls

6

12,200.21

0.49 (0.22–1.09)

Ref

66

12,164.32

5.43 (4.27–6.90)

Ref

 > 40 years

Authorized to use cannabis

96

9579.22

10.02 (8.21–12.23)

1.42 (1.05–1.92)

351

9456.13

37.12 (33.50–41.13)

1.47 (1.25–1.73)

Controls

217

27,142.35

7.99 (7.00–9.13)

Ref

676

26,879.91

25.15 (23.35–27.09)

Ref

  1. The p-value for interaction between age (as dichotomous variable) and cannabis authorization is 0.6015 for the primary outcome and 0.9412 for the secondary outcome
  2. *Conditional Cox model further adjusted for history of any CV event and area of living