Aortic root aortopathy in bicuspid aortic valve associated with high genetic risk

Table 3 Comparing aortopathy and normal ascending aorta

Variables	Normal aorta (n = 62)	Tubular aortopathy (n = 27)	Root aortopathy (n = 7)	P value
Variables	Normal aorta (n = 62)	Tubular aortopathy (n = 27)	Root aortopathy (n = 7)	Total
Onset age (years)	41.7 ± 12.7	53.6 ± 8.9 *	35.0 ± 11.8	< 0.001
Male (%)	40 (75.8)	22 (81.5)	5 (71.4)	0.878
Diabetes mellitus (%)	6 (9.7)	5 (18.5)	2 (28.6)	0.102
Hypertension (%)	24 (38.7)	9 (33.3)	0	0.081
Variant burden (%)	14 (22.6)	6 (22.2)	5 (71.4) ^†	0.018
Aortic dissection (%)	2 (3.2)	3 (11.1)	2 (28.6)	0.024
Infective endocarditis (%)	14 (22.6)	3 (11.1)	0	0.070
Multiple valves replacement (%)	15 (24.2)	1 (3.7)	1 (14.3)	0.070

^*With the ANOVA test for the onset age, statistically significant difference was found between normal aorta, tubular aortopathy and root aortopathy groups. Tubular group is the oldest according to the post-hoc test
^†For variant burden, Chi-square test indicated a statistically significant difference between three groups. Adjusted residual for root group was 2.3 (p = 0.00045), reaching the threefold Bonferroni-adjusted significance level of p < 0.0167)

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