Abnormalities in lysine degradation are involved in early cardiomyocyte hypertrophy development in pressure-overloaded rats

Table 2 Significantly different metabolites identified 3 weeks after TAC surgery

Name of metabolites	Category	VIP	FC	p
5-Aminopentanoic acid	Amino acids, peptides	1.13	1.45	0.004
N6-Acetyl-l-lysine	Amino acids, peptides	1.21	1.46	0.023
l-Lysine	Amino acids, peptides	9.94	1.30	0.028
ε-Caprolactam	Others	2.91	1.40	0.029
γ-l-Glu-ε-l-lysine	Others	2.96	1.45	0.030
N6-Methyl-l-lysine	Amino acids, peptides	2.17	1.34	0.033
N2-Acetyl-l-ornithine	Amino acids, peptides	1.12	0.78	0.034
Thioetheramide-PC	Others	1.12	1.40	0.036
5-Methylcytosine	Pyrimidines	2.72	0.82	0.037
Pentadecanoic Acid	Fatty acids	3.08	0.50	0.003
d(−)-β-Hydroxybutyric acid	Others	2.11	2.31	0.008
Nervonic acid	Fatty acids	2.05	0.44	0.018
l-Phenylalanine	Amino acids, peptides	2.47	1.41	0.030

TAC: transverse aortic constriction; VIP: variable importance in projection; FC: fold change

ISSN: 1471-2261