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Table 4 Topology table for up and down regulated genes

From: Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis

Regulation

Node

Degree

Betweenness

Stress

Closeness

Up

ESR1

1094

0.250896

7.4E+08

0.392769

Up

PYHIN1

342

0.054258

1.1E+08

0.339882

Up

PPP2R2B

199

0.023115

35,268,762

0.346839

Up

LCK

162

0.033618

18,589,354

0.353915

Up

TP63

142

0.018577

39,426,608

0.319664

Up

CD247

129

0.013832

18,625,274

0.317784

Up

PTN

105

0.016638

36,892,166

0.300662

Up

APLNR

103

0.016611

40,715,208

0.288093

Up

APOA1

100

0.018834

13,935,332

0.315866

Up

CENPA

98

0.009846

31,131,318

0.301786

Up

SKAP1

97

0.01599

10,109,482

0.313338

Up

FSCN1

88

0.010226

9,387,016

0.335367

Up

SCN2B

86

0.01089

24,233,242

0.284756

Up

TMEM30B

79

0.016411

10,490,230

0.270807

Up

FOXS1

79

0.009408

26,398,078

0.293247

Up

COL1A1

76

0.010472

9,315,670

0.308098

Up

ZAP70

75

0.007096

5,315,196

0.317614

Up

UCHL1

74

0.009753

9,381,024

0.331525

Up

HBB

72

0.009984

14,209,592

0.304767

Up

NRG1

70

0.01151

13,449,066

0.29526

Up

LEF1

61

0.007998

18,260,094

0.290744

Up

NT5E

60

0.009599

11,470,634

0.301563

Up

MDK

59

0.006889

7,533,352

0.305822

Up

ISLR

58

0.010139

9,992,806

0.294012

Up

FATE1

57

0.011609

9,248,788

0.281581

Up

LRRC15

56

0.010069

4,772,792

0.299094

Up

MATN2

54

0.004491

9,580,600

0.286792

Up

LIPH

54

0.008197

6,873,658

0.282347

Up

MYOC

49

0.005138

12,313,276

0.291029

Up

SCARA3

49

0.006492

11,494,220

0.290151

Up

NPPA

46

0.009502

4,868,574

0.307143

Up

CD83

43

0.005149

5,484,906

0.272841

Up

COL14A1

41

0.006129

5,699,128

0.292893

Up

CTSG

40

0.003821

1,913,996

0.296155

Up

SFRP4

40

0.004006

7,876,966

0.282518

Up

TRAF3IP3

38

0.006447

4,263,002

0.290602

Up

CLEC11A

38

0.005085

3,520,012

0.283596

Up

ATP1B4

38

0.005722

2,476,482

0.245939

Up

CD3E

37

0.003892

1,537,326

0.297624

Up

SH2D1A

37

0.003969

2,117,220

0.308113

Up

DDX3Y

37

0.003754

1,632,916

0.32095

Up

PRPH

37

0.001871

1,994,266

0.301494

Up

BIRC7

35

0.004835

2,567,254

0.28549

Up

CARD11

35

0.002249

2,510,852

0.292173

Up

RXRG

35

0.002394

7,134,478

0.26225

Up

CCL22

34

0.005706

3,916,024

0.281423

Up

CD27

33

0.003915

2,076,446

0.294263

Up

GZMB

32

0.003277

6,141,522

0.285602

Up

THY1

32

0.003561

1,793,684

0.291509

Up

CHRNA3

32

0.004247

3,415,720

0.236631

Up

LSP1

32

0.003371

5,734,010

0.281836

Up

IL2RB

31

0.002351

1,938,172

0.305808

Up

HTR2B

30

0.004018

2,165,998

0.27434

Up

DLGAP1

29

0.003816

6,072,882

0.277754

Up

TRIM17

29

0.002943

5,543,810

0.275137

Up

CTNNA2

29

0.003554

3,511,510

0.30254

Up

SERPINE2

28

0.002577

3,031,536

0.27426

Up

CD1E

28

0.003282

3,419,392

0.255229

Up

MRC2

28

0.003395

2,950,548

0.296276

Up

C1QTNF2

28

0.003203

2,505,388

0.270147

Up

SH2D1B

27

0.001864

1,043,570

0.29028

Up

BRINP1

27

0.001516

4,402,948

0.27726

Up

PDIA2

27

0.001967

2,895,182

0.286453

Up

CHD5

27

0.001918

5,223,636

0.286503

Up

FAP

27

0.003531

5,820,086

0.268583

Up

IL31RA

26

0.002073

1,606,954

0.263603

Up

GAP43

25

0.002745

2,793,268

0.279858

Up

CD5

25

0.001695

655,904

0.295861

Up

UBASH3A

25

0.001652

1,347,264

0.290951

Up

ROBO2

25

0.002959

3,726,616

0.267048

Up

ITGB7

24

0.002686

3,351,660

0.276124

Up

HTR2A

24

0.002571

2,472,010

0.275833

Up

MOXD1

24

0.002391

2,492,756

0.259926

Up

ASB18

24

9.77E−04

3,202,162

0.273001

Up

CD2

23

0.002221

926,408

0.287954

Up

BCL11B

23

8.18E−04

1,888,298

0.28836

Up

STAT4

23

0.001786

2,435,506

0.277166

Up

NGEF

23

0.001809

1,548,206

0.277636

Up

SMPD3

23

0.002518

2,175,774

0.281

Up

FZD2

22

0.003673

3,239,390

0.250335

Up

DUSP15

22

0.001253

2,474,532

0.284472

Up

CD3D

21

0.001725

1,111,132

0.288589

Up

SYT17

21

0.002549

2,482,574

0.285802

Up

FCGR3B

21

0.002748

1,492,022

0.282286

Up

EGR2

21

0.002934

3,438,856

0.266406

Up

ZBP1

21

0.001876

2,664,938

0.26006

Up

CAMK4

21

0.001773

3,472,134

0.272716

Up

DMC1

20

0.002511

4,659,098

0.254277

Up

GDNF

20

0.002515

3,274,958

0.244751

Up

FCN1

20

0.002571

1,243,380

0.236742

Up

LUM

20

0.002276

1,515,870

0.283903

Up

GZMA

20

0.001051

3,258,230

0.276498

Up

TGFB2

20

0.002259

1,632,566

0.277119

Up

SLAMF7

20

0.00211

1,035,482

0.271708

Up

MS4A1

20

0.002857

1,169,078

0.288398

Up

ETV4

20

0.001747

1,674,080

0.301883

Up

GLI2

20

0.001398

2,977,194

0.285902

Up

PHLDA1

19

4.37E−04

818,256

0.298194

Up

COL8A2

19

0.00147

1,089,762

0.273835

Up

GABRD

19

0.002826

2,629,544

0.25748

Up

LMF1

19

0.004342

2,024,228

0.265132

Up

F2RL2

19

0.001554

790,338

0.282933

Up

LYPD1

19

0.003123

3,995,458

0.266276

Up

CAPN6

19

0.001415

3,046,736

0.267802

Up

SOX8

19

0.003361

2,763,024

0.251306

Up

IER3

18

0.001921

3,613,164

0.282982

Up

BEX1

18

0.001034

1,286,206

0.273606

Up

COLQ

18

0.001173

1,414,826

0.261234

Up

NTM

18

0.00284

2,486,684

0.275102

Up

RPS4Y1

18

0.001013

1,200,768

0.287713

Up

FERMT1

18

0.001713

4,279,868

0.270315

Up

RGS17

18

0.002928

3,868,106

0.249895

Up

TNNI1

17

0.001349

1,550,004

0.266765

Up

MYOZ1

17

0.00128

2,111,156

0.283203

Up

KLHDC8A

17

0.001147

7,007,508

0.251036

Up

MYL1

17

7.90E−04

1,213,666

0.289945

Up

DIO2

16

0.001161

1,959,228

0.279416

Up

ITGAL

16

0.001182

1,521,116

0.271527

Up

CRABP2

16

4.13E−04

675,182

0.272171

Up

HSH2D

16

0.001425

889,856

0.26034

Up

CD48

3

0

0

0.265422

Up

CD3G

2

0

0

0.23833

Up

LY9

2

0

0

0.240141

Up

SIT1

2

0

0

0.264221

Up

ATP1A4

2

1.16E−04

79,140

0.235049

Up

FMOD

2

3.96E−05

20,526

0.240707

Up

CCDC80

2

3.58E−05

499,704

0.288908

Up

CCR7

2

0

0

0.244312

Up

KCNIP1

1

0

0

0.219995

Up

CD6

1

0

0

0.22832

Up

FCRL3

1

0

0

0.241062

Up

SERTAD4

1

0

0

0.257531

Up

PRF1

1

0

0

0.222162

Up

C1QTNF9

1

0

0

0.226548

Up

OPCML

1

0

0

0.215756

Up

ESM1

1

0

0

0.213551

Up

CD40LG

1

0

0

0.240053

Up

S1PR5

1

0

0

0.24224

Up

AGTR2

1

0

0

0.259256

Up

NPPB

1

0

0

0.211726

Up

SCG5

1

0

0

0.238721

Up

PDE5A

1

0

0

0.243548

Up

RYR3

1

0

0

0.274755

Up

RASEF

1

0

0

0.274755

Up

PODXL2

1

0

0

0.213106

Up

OGN

1

0

0

0.226548

Up

PLCH2

1

0

0

0.238721

Up

SCG2

1

0

0

0.267704

Up

P3H2

1

0

0

0.207132

Up

C12orf75

1

0

0

0.217608

Up

ACE

1

0

0

0.241159

Up

GNA14

1

0

0

0.217608

Up

HDC

1

0

0

0.216614

Up

CMA1

1

0

0

0.226713

Up

CEACAM3

1

0

0

0.265519

Down

PCLAF

817

0.135529

4.95E+08

0.365547

Down

CFTR

800

0.168404

4.5E+08

0.378823

Down

TK1

188

0.034997

43,663,230

0.331089

Down

ECT2

164

0.020509

39,431,940

0.325989

Down

FKBP5

157

0.028064

15,963,868

0.346288

Down

ANLN

153

0.021564

38,168,832

0.325066

Down

ATP2A2

148

0.027131

19,656,040

0.363859

Down

BCL6

142

0.022279

29,419,916

0.314181

Down

TOP2A

132

0.018571

16,838,266

0.361426

Down

ZBTB16

132

0.025165

14,500,206

0.349976

Down

S100A9

124

0.01355

11,186,464

0.352219

Down

CEP55

123

0.019583

21,505,878

0.316891

Down

BLM

108

0.014259

18,458,556

0.321945

Down

AGTR1

100

0.019518

14,083,216

0.313564

Down

SAMHD1

94

0.011463

12,340,270

0.337357

Down

S100A8

88

0.011637

8,662,548

0.361486

Down

GRAP2

86

0.011721

16,819,438

0.305936

Down

CBS

83

0.011248

20,466,334

0.301591

Down

SOCS3

83

0.011071

9,067,820

0.324888

Down

GFI1B

80

0.011791

21,469,034

0.299012

Down

APOB

78

0.014102

9,290,092

0.319133

Down

PCK1

77

0.004102

12,732,476

0.305408

Down

MARK3

76

0.008497

19,265,788

0.304512

Down

HMOX2

75

0.011098

15,258,770

0.312053

Down

PCNT

74

0.011297

9,190,430

0.312261

Down

PIK3C2A

69

0.005568

8,768,122

0.313053

Down

KIF14

69

0.01035

12,506,564

0.304668

Down

WASF1

67

0.009478

18,219,554

0.29633

Down

ARNTL

65

0.00974

19,494,854

0.295526

Down

ALOX5

65

0.010921

7,343,824

0.306424

Down

MCM10

64

0.006773

8,807,396

0.306438

Down

THBS1

64

0.008915

6,203,038

0.312694

Down

VSIG4

64

0.010353

10,534,518

0.302037

Down

WWC1

64

0.007241

14,604,594

0.301647

Down

MELK

63

0.008554

18,629,232

0.283953

Down

P2RY12

63

0.008962

9,063,088

0.286641

Down

PPL

62

0.007851

16,137,388

0.297313

Down

MYBL2

59

0.006189

16,766,208

0.291964

Down

FAM107A

59

0.006172

12,510,302

0.289688

Down

GRIP1

58

0.008069

3,384,760

0.320055

Down

ELF3

56

0.004945

7,205,142

0.309118

Down

PALLD

55

0.00509

15,467,012

0.293274

Down

CTH

54

0.007754

5,179,060

0.296908

Down

EIF4EBP1

53

0.005367

9,748,852

0.303946

Down

KNG1

53

0.007017

4,204,766

0.304243

Down

GLUL

51

0.00728

10,616,752

0.30116

Down

SLC2A1

51

0.004557

8,307,646

0.303974

Down

HP

51

0.006741

3,398,298

0.314741

Down

RPGR

50

0.004441

10,097,488

0.29384

Down

TLR2

50

0.00754

8,322,330

0.294595

Down

GRB7

49

0.004147

4,832,846

0.308113

Down

PPEF1

49

0.001983

3,327,232

0.298276

Down

TXNRD1

49

0.00627

2,860,122

0.328561

Down

NAMPT

48

0.005035

10,420,710

0.290538

Down

BMP7

47

0.007622

4,442,306

0.286981

Down

CA14

47

0.005218

4,884,858

0.279189

Down

CCR1

46

0.008305

11,217,842

0.27812

Down

CDC45

45

0.004479

3,231,162

0.30618

Down

ARG1

45

0.004931

2,347,856

0.32381

Down

SPC24

43

0.005356

6,589,710

0.294834

Down

FGR

43

0.003434

3,020,950

0.303452

Down

KIF5C

42

0.004876

2,365,086

0.319586

Down

IL1R2

42

0.006825

9,489,620

0.289265

Down

SERPINA3

42

0.005518

4,047,110

0.293168

Down

DEPDC1B

42

0.002978

9,632,346

0.260838

Down

SLC4A7

41

0.006314

2,752,106

0.316232

Down

SERPINA5

41

0.003604

13,750,404

0.273206

Down

MPP3

40

0.008262

9,328,402

0.297003

Down

NCEH1

40

0.009405

3,554,728

0.304214

Down

SLC1A1

38

0.008678

2,278,154

0.320573

Down

CLSPN

38

0.003668

3,801,300

0.294343

Down

BCAT1

38

0.0052

9,066,238

0.269657

Down

MYH6

38

0.005049

1,731,786

0.308578

Down

IL20RA

37

0.005252

8,769,348

0.267901

Down

HOOK1

37

0.005558

7,195,380

0.279177

Down

FLT3

37

0.002948

1,938,440

0.292408

Down

ADAMTS4

37

0.005524

2,338,476

0.307519

Down

CAMSAP3

36

0.003339

4,795,892

0.29578

Down

PLA2G2A

35

0.003637

1,686,594

0.300565

Down

FOSL1

34

0.004151

10,955,318

0.269402

Down

NQO1

34

0.001945

5,351,260

0.289201

Down

ELANE

34

0.005024

2,289,646

0.302834

Down

KCND3

34

0.002555

9,153,178

0.28203

Down

EPN3

34

0.005073

7,423,282

0.280302

Down

GPR183

34

0.003642

4,243,792

0.256783

Down

CD109

34

0.006381

3,655,940

0.303565

Down

TUBA3E

34

0.003459

6,711,886

0.289048

Down

TGFBR3

33

0.005143

1,983,082

0.267386

Down

NID1

33

0.004536

1,702,236

0.311503

Down

STEAP3

33

0.004665

2,788,716

0.285365

Down

AMD1

32

0.005714

3,154,782

0.29099

Down

EDNRB

31

0.003092

7,273,156

0.265368

Down

IL17RB

31

0.004227

6,381,040

0.261527

Down

SLC19A2

30

0.004653

2,505,974

0.281302

Down

SLC22A16

30

0.004545

3,831,872

0.240618

Down

PHACTR3

29

0.002193

6,417,862

0.280976

Down

LAPTM5

29

0.003298

2,735,158

0.274317

Down

ANGPTL4

29

0.003467

1,447,446

0.325163

Down

PPM1E

29

0.002894

5,733,032

0.270427

Down

E2F2

28

0.002816

5,508,320

0.28041

Down

SERPINE1

28

0.001474

2,497,574

0.271302

Down

ACPP

28

0.003084

2,749,550

0.291223

Down

KRT7

28

0.002861

1,288,592

0.315774

Down

SERPINB8

28

0.002944

3,167,812

0.28186

Down

FREM2

28

0.003954

3,395,758

0.276661

Down

RNF157

28

0.002172

6,196,626

0.265551

Down

PPIP5K2

28

0.003886

8,572,108

0.270014

Down

F8

27

0.002839

4,879,016

0.274836

Down

TUBAL3

27

0.002055

1,052,840

0.318915

Down

ELL2

26

0.003971

6,281,508

0.255859

Down

GRB14

25

0.002326

3,092,024

0.28378

Down

IRAK3

25

0.00257

6,900,170

0.265897

Down

MANEA

25

0.004508

5,075,608

0.263869

Down

CLEC7A

25

0.004246

4,293,212

0.277095

Down

KLF10

24

0.001607

3,013,994

0.281339

Down

GNMT

24

0.00165

3,015,768

0.269136

Down

ART3

24

0.002904

2,401,360

0.255748

Down

LRRC8E

24

0.003739

4,188,308

0.288665

Down

SLA

23

0.001714

1,003,510

0.289329

Down

CLEC4G

23

0.002667

2,376,260

0.277495

Down

TUBB4A

5

1.28E−04

181,440

0.250652

Down

CD38

4

0

0

0.268176

Down

FCGR3A

4

1.01E−04

73,756

0.268385

Down

F5

3

8.10E−07

708

0.248641

Down

EHF

2

7.11E−06

4180

0.254842

Down

KIAA1549

2

4.16E−04

193,604

0.261391

Down

S100A3

2

1.84E−05

45,822

0.254376

Down

ADH1B

2

3.40E−05

28,184

0.233546

Down

PAPSS2

2

1.05E−05

8726

0.251868

Down

PTX3

1

0

0

0.19143

Down

IL15RA

1

0

0

0.234199

Down

EDN1

1

0

0

0.209723

Down

SERPINF2

1

0

0

0.232451

Down

ZNF366

1

0

0

0.282018

Down

ACR

1

0

0

0.214588

Down

MATN3

1

0

0

0.222881

Down

CNR1

1

0

0

0.216205

Down

LBP

1

0

0

0.240053

Down

ALOX5AP

1

0

0

0.23456

Down

SCGN

1

0

0

0.23353

Down

MAMDC2

1

0

0

0.248745

Down

CDKL5

1

0

0

0.219891

Down

CENPM

1

0

0

0.231833

Down

KCNIP2

1

0

0

0.219995

Down

CPM

1

0

0

0.24533

Down

GPSM2

1

0

0

0.245855

Down

LSAMP

1

0

0

0.215756

Down

KCNK3

1

0

0

0.219353

Down

ALOX15B

1

0

0

0.234981

Down

ST6GALNAC3

1

0

0

0.233263

Down

GPRC5A

1

0

0

0.274755

Down

SLC31A2

1

0

0

0.215287

Down

MARVELD2

1

0

0

0.218671

Down

SNTG2

1

0

0

0.229

Down

TRHDE

1

0

0

0.208786

Down

SIGLEC7

1

0

0

0.245229

Down

SMTNL2

1

0

0

0.265519

Down

ANXA3

1

0

0

0.274755

Down

F13A1

1

0

0

0.248745

Down

ANKRD7

1

0

0

0.233438

Down

KCNS2

1

0

0

0.219721

Down

SIGLEC9

1

0

0

0.227565

Down

SIGLEC10

1

0

0

0.282018

Down

C20orf197

1

0

0

0.282018

Down

SCGB1D2

1

0

0

0.226548

Down

IL1RL1

1

0

0

0.21698

Down

PLIN2

1

0

0

0.241935

Down

CD163

1

0

0

0.239403

Down

HPR

1

0

0

0.240053

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BMC Cardiovascular Disorders

ISSN: 1471-2261

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