From: Leukocyte count and the risk of adverse outcomes in patients with HFpEF
All-cause mortality | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
HR | 95%CI | p-value | HR | 95%CI | p-value | |
Age | 1.054 | 1.043–1.065 | 0.000 | 1.046 | 1.033–1.059 | 0.000 |
Sex | 0.67 | 0.554–0.810 | 0.000 | 1.698 | 1.368–2.106 | 0.000 |
Race | 1.528 | 1.251–1.867 | 0.000 | 0.037 | ||
0.531 | 0.326–0.865 | 0.011 | ||||
0.591 | 0.332–1.049 | 0.073 | ||||
BMI | 1.007 | 0.993–1.021 | 0.330 | – | – | – |
Smoker | 1.170 | 1.037–1.320 | 0.011 | – | – | – |
LVEF | 0.998 | 0.984–1.013 | 0.820 | – | – | – |
Angina pectoris | 0.613 | 0.504–0.745 | 0.000 | 0.815 | 0.653–1.017 | 0.071 |
Prior heart failure hospitalization | 0.810 | 0.657–0.997 | 0.047 | 1.124 | 0.901–1.403 | 0.301 |
Previous myocardial infarction | 1.266 | 1.026–1.563 | 0.028 | 0.777 | 0.603–1.002 | 0.052 |
Stroke | 1.558 | 1.151–2.110 | 0.004 | 0.940 | 0.686–1.289 | 0.702 |
CABG | 1.655 | 1.293–2.118 | 0.000 | 1.066 | 0.800–1.422 | 0.661 |
PCI | 1.483 | 1.161–1.893 | 0.002 | 1.061 | 0.803–1.403 | 0.677 |
COPD | 1.629 | 1.257–2.111 | 0.000 | 0.936 | 0.713–1.228 | 0.634 |
Asthma | 1.601 | 1.152–2.226 | 0.005 | 0.812 | 0.574–1.148 | 0.239 |
Hypertension | 0.815 | 0.586–1.133 | 0.223 | – | – | – |
Peripheral arterial disease | 2.154 | 1.669–2.779 | 0.000 | 0.615 | 0.468–0.809 | 0.001 |
Dyslipidemia | 1.271 | 1.043–1.550 | 0.018 | 1.105 | 0.857–1.426 | 0.441 |
ICD | 1.605 | 0.797–3.230 | 0.185 | – | – | – |
Pacemaker | 1.983 | 1.500–2.621 | 0.000 | 0.978 | 0.724–1.320 | 0.884 |
Atrial fibrillation | 1.530 | 1.264–1.851 | 0.000 | 1.016 | 0.821–1.258 | 0.884 |
Thyroid disease | 1.219 | 0.957–1.553 | 0.108 | – | – | – |
Diabetes mellitus | 0.595 | 0.491–0.721 | 0.000 | 0.857 | 0.685–1.071 | 0.175 |
Heart rate | 1.017 | 1.008–1.026 | 0.000 | 1.021 | 1.012–1.031 | 0.000 |
Systolic blood pressure | 0.981 | 0.974–0.988 | 0.000 | 0.992 | 0.984–1.000 | 0.050 |
Diastolic blood pressure | 0.959 | 0.951–0.967 | 0.000 | 0.994 | 0.982–1.006 | 0.300 |
Fasting glucose | 1.002 | 0.998–1.005 | 0.343 | – | – | – |
New York Heart Association class III-IV | 1.723 | 1.423–2.086 | 0.000 | 0.806 | 0.658–0.988 | 0.038 |
eGFR | 0.979 | 0.973–0.984 | 0.000 | 0.994 | 0.988–1.000 | 0.055 |
Leukocyte group | 1.249 | 1.146–1.361 | 0.000 | 0.000 | ||
1 | 1.439 | 1.060–1.953 | 0.020 | |||
2 | Reference | |||||
3 | 1.510 | 1.113–2.050 | 0.008 | |||
4 | 1.901 | 1.424–2.539 | 0.000 | |||
Hemoglobin | 0.833 | 0.786–0.882 | 0.000 | 0.898 | 0.843–0.958 | 0.001 |
BUN | 1.030 | 1.025–1.036 | 0.000 | 1.009 | 1.001–1.017 | 0.023 |
Albumin | 0.983 | 0.945–1.023 | 0.411 | – | – | – |
Aspirin | 1.301 | 1.074–1.576 | 0.007 | 1.089 | 0.884–1.341 | 0.424 |
b-blockers | 1.16 | 0.915–1.471 | 0.220 | – | – | – |
ACEi | 1.355 | 1.116–1.643 | 0.002 | 0.945 | 0.770–1.160 | 0.591 |
ARB | 0.862 | 0.670–1.109 | 0.248 | – | – | – |
Statin | 0.726 | 0.599–0.878 | 0.001 | 1.072 | 0.837–1.372 | 0.581 |
Loop diuretic | 0.304 | 0.245–0.377 | 0.000 | 0.553 | 0.423–0.724 | 0.000 |
Thiazide Diuretic | 0.494 | 0.398–0.612 | 0.000 | 1.080 | 0.840–1.388 | 0.548 |
Spironolactone | 1.029 | 0.851–1.243 | 0.769 | – | – | – |