Table 4 The correlation of kynurenine and IDO activity levels and severity of CAD in the presence of heart failure, diabetes mellitus and valvular heart disease
From: Indoleamine 2,3 dioxygenase (IDO) level as a marker for significant coronary artery disease
Insignificant CAD (n = 78) | Significant CAD (n = 227) | p-value | |
|---|---|---|---|
All patients (n = 305) | |||
Baseline Kynurenine | 2.74 (0.00, 70.58) | 5.36 (0.00, 11,731.00) | 0.007 |
Baseline IDO activity | 0.03 (0.00, 3.78) | 0.16 (0.00, 4.58) | 0.001 |
Excluded pre-op for VHD (n = 279) | n = 59 | n = 220 | |
|---|---|---|---|
Baseline Kynurenine | 1.00 (0.00, 70.58) | 5.37 (0.00, 11,731.00) | 0.005 |
Baseline IDO activity | 0.02 (0.00, 3.78) | 0.16 (0.00, 4.58) | 0.001 |
In presence of HF (n = 66) | n = 41 | n = 25 | |
|---|---|---|---|
Baseline Kynurenine | 4.97 (0.00, 70.58) | 1.21 (0.00, 44.63) | 0.358 |
Baseline IDO activity | 0.09 (0.00, 3.78) | 0.03 (0.00, 1.22) | 0.512 |
Excluded HF (n = 239) | n = 37 | n = 202 | |
|---|---|---|---|
Baseline Kynurenine | 0.82 (0.00, 42.74) | 5.62 (0.00, 11,731.00) | 0.002 |
Baseline IDO activity | 0.01 (0.00, 1.28) | 0.17 (0.00, 4.58) | < 0.001 |
In presence of DM (N = 134) | n = 25 | n = 109 | |
|---|---|---|---|
Baseline Kynurenine | 4.60 (0.00, 34.41) | 4.90(0.00, 11,731.00) | 0.276 |
Baseline IDO activity | 0.11 (0.00, 0.71) | 0.15 (0.00, 3.71) | 0.107 |
Excluded DM (n = 171) | n = 53 | n = 118 | |
|---|---|---|---|
Baseline Kynurenine | 1.84 (0.00, 70.58) | 5.73(0.00, 10,639.00) | 0.009 |
Baseline IDO activity | 0.02 (0.00, 3.78) | 0.16 (0.00, 4.58) | 0.002 |