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Table 3 Univariable and multivariable adjustment for factors associated with POCD at 48 h after ablation in the study group

From: Incidence and risk factors of post-operative cognitive decline after ablation for atrial fibrillation

Variable Patients with POCD (n = 26) Patients without POCD (n = 164) Univariable adjustment Multivariable adjustment
OR 95% CI P value OR 95% CI P value
Age (years) 67.7 ± 6.3 66.4 ± 5.3 1.04 0.97–1.12 0.26
Male 12 (46.2) 101 (61.6) 1.87 0.81–4.30 0.14
College and above 5 (19.2) 52 (31.7) 0.51 0.18–1.44 0.20
Paroxysmal atrial fibrillation 17 (65.4) 114 (69.5) 1.21 0.50–2.89 0.67
Diabetes 3 (11.5) 30 (18.3) 0.58 0.16–2.07 0.40
Hypertension 16 (61.5) 106 (64.6) 0.88 0.37–2.05 0.76
Dyslipidemia 4 (15.4) 37 (22.6) 0.62 0.20–1.93 0.41
Coronary artery disease 6(23.1) 24 (14.6) 1.75 0.64–4.80 0.28
Heart failure 3 (11.5) 7 (4.3) 2.96 0.71–12.12 0.14
Smoker 4 (15.4) 29 (17.7) 0.85 0.27–2.64 0.77
Oral antiplatelet drugs 4 (15.4) 15 (9.1) 1.81 0.55–5.94 0.33
ACEI/ARB 10 (38.5) 47 (28.7) 1.56 0.66–3.68 0.31
Statins 13 (50.0) 78 (47.6) 1.10 0.48–2.52 0.82
CHA2DS2-VASc score (< 2 for males, < 3 for females) 11 (42.3) 78 (47.6) 0.81 0.35–1.87 0.62 0.95 0.38–2.39 0.91
Level of depression 2.6 ± 1.4 2.7 ± 1.2 0.93 0.66–1.30 0.67
Level of anxiety 3.7 ± 1.6 3.8 ± 1.3 0.97 0.70–1.34 0.85
Intraoperative hypotension 0 (0.0) 2 (1.2) 0.00 0.00 1.00
Direct current cardioversion 7 (26.9) 34 (20.7) 1.41 0.55–3.63 0.48
Minimum intraoperative ACT < 300 s 12 (46.2) 38 (23.2) 2.84 1.21–6.66 0.02* 3.82 1.48–9.96 0.006*
Left atrial access time (min) 125.6 ± 32.6 120.2 ± 38.1 1.00 0.99–1.01 0.50
Radiofrequency duration (min) 83.1 ± 31.0 80.0 ± 34.1 1.00 0.99–1.02 0.66
Fentanyl dosage (μg) 161.3 ± 45.3 160.5 ± 48.4 1.00 0.99–1.01 0.93
Not on oral anticoagulant within 1-month prior to ablation 21 (80.8) 53 (32.3) 8.80 3.14–24.6  < 0.001* 10.35 3.54–30.27  < 0.001*
No oral anticoagulants interruption 3 (11.5) 24 (14.6) 0.76 0.21–2.73 0.68
  1. Values are presented as the mean ± SD or n (%)
  2. OR, odds ratio; CI, confidence interval; the asterisk indicates statistical significance