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Table 3 Univariable and multivariable adjustment for factors associated with POCD at 48 h after ablation in the study group

From: Incidence and risk factors of post-operative cognitive decline after ablation for atrial fibrillation

Variable

Patients with POCD (n = 26)

Patients without POCD (n = 164)

Univariable adjustment

Multivariable adjustment

OR

95% CI

P value

OR

95% CI

P value

Age (years)

67.7 ± 6.3

66.4 ± 5.3

1.04

0.97–1.12

0.26

–

–

–

Male

12 (46.2)

101 (61.6)

1.87

0.81–4.30

0.14

–

–

–

College and above

5 (19.2)

52 (31.7)

0.51

0.18–1.44

0.20

–

–

–

Paroxysmal atrial fibrillation

17 (65.4)

114 (69.5)

1.21

0.50–2.89

0.67

–

–

–

Diabetes

3 (11.5)

30 (18.3)

0.58

0.16–2.07

0.40

–

–

–

Hypertension

16 (61.5)

106 (64.6)

0.88

0.37–2.05

0.76

–

–

–

Dyslipidemia

4 (15.4)

37 (22.6)

0.62

0.20–1.93

0.41

–

–

–

Coronary artery disease

6(23.1)

24 (14.6)

1.75

0.64–4.80

0.28

–

–

–

Heart failure

3 (11.5)

7 (4.3)

2.96

0.71–12.12

0.14

–

–

–

Smoker

4 (15.4)

29 (17.7)

0.85

0.27–2.64

0.77

–

–

–

Oral antiplatelet drugs

4 (15.4)

15 (9.1)

1.81

0.55–5.94

0.33

–

–

–

ACEI/ARB

10 (38.5)

47 (28.7)

1.56

0.66–3.68

0.31

–

–

–

Statins

13 (50.0)

78 (47.6)

1.10

0.48–2.52

0.82

–

–

–

CHA2DS2-VASc score (< 2 for males, < 3 for females)

11 (42.3)

78 (47.6)

0.81

0.35–1.87

0.62

0.95

0.38–2.39

0.91

Level of depression

2.6 ± 1.4

2.7 ± 1.2

0.93

0.66–1.30

0.67

–

–

–

Level of anxiety

3.7 ± 1.6

3.8 ± 1.3

0.97

0.70–1.34

0.85

–

–

–

Intraoperative hypotension

0 (0.0)

2 (1.2)

0.00

0.00

1.00

–

–

–

Direct current cardioversion

7 (26.9)

34 (20.7)

1.41

0.55–3.63

0.48

–

–

–

Minimum intraoperative ACT < 300 s

12 (46.2)

38 (23.2)

2.84

1.21–6.66

0.02*

3.82

1.48–9.96

0.006*

Left atrial access time (min)

125.6 ± 32.6

120.2 ± 38.1

1.00

0.99–1.01

0.50

–

–

–

Radiofrequency duration (min)

83.1 ± 31.0

80.0 ± 34.1

1.00

0.99–1.02

0.66

–

–

–

Fentanyl dosage (μg)

161.3 ± 45.3

160.5 ± 48.4

1.00

0.99–1.01

0.93

–

–

–

Not on oral anticoagulant within 1-month prior to ablation

21 (80.8)

53 (32.3)

8.80

3.14–24.6

 < 0.001*

10.35

3.54–30.27

 < 0.001*

No oral anticoagulants interruption

3 (11.5)

24 (14.6)

0.76

0.21–2.73

0.68

–

–

–

  1. Values are presented as the mean ± SD or n (%)
  2. OR, odds ratio; CI, confidence interval; the asterisk indicates statistical significance
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BMC Cardiovascular Disorders

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