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Table 5 Results of Cox proportional hazard regression models

From: IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study

  N All-cause mortality CV mortality Hospitalization CV hospitalization
HR[95CI] p HR[95CI] p HR[95CI] p HR[95CI] p
IGFBP7
Univariate 1634 17.17
[11.31–26.05]
1.1 × 10−40 31.7
[15.06–66.87]
9.8 × 10−20 2.31
[1.66–3.21]
7.5 × 10−7 4.48
[2.89–6.96]
2.5 × 10−11
Multivariable 1486 5.20
[2.79–9.68]
2.0 × 10−7 7.73
[2.28–26.26]
0.001 1.50
[0.99–2.28]
0.057 2.26
[1.27–4.01]
0.006
Multivariable + echo 809 4.25
[1.81–9.99]
0.001 2.52
[0.47–13.39]
0.279 1.11
[0.61–2.01]
0.733 1.65
[0.76–3.57]
0.204
Multivariable + biomarkers 1486 2.13
[1.08–4.22]
0.029 1.97
[0.51–7.66]
0.329 0.94
[0.60–1.48]
0.794 1.04
[0.55–1.94]
0.911
GDF-15
Univariate 1705 3.44
[2.95–4.02]
4.0 × 10−56 3.96
[2.92–5.36]
6.0 × 10−19 1.60
[1.42–1.80]
3.0 × 10−14 1.91
[1.63–2.24]
2.3 × 10−15
Multivariable 1621 2.58
[2.09–3.20]
2.5 × 10−18 2.84
[1.82–4.43]
4.0 × 10−6 1.32
[1.13–1.53]
3.3 × 10−4 1.50
[1.21–1.84]
1.2 × 10−4
Multivariable + echo 843 2.50
[1.82–3.44]
1.9 × 10−8 1.89
[0.96–3.73]
0.067 1.42
[1.15–1.77]
0.001 1.44
[1.09–1.92]
0.011
Multivariable + biomarkers 1621 2.03
[1.62–2.56]
1.5 × 10−9 1.75
[1.06–2.88]
0.028 1.17
[0.99–1.37]
0.059 1.22
[0.98–1.53]
0.079
  1. Cox proportional hazard models for all-cause mortality or hospital admission for cardiovascular reason. HR [95%CI] for Ln-transformed concentration of the biomarker
  2. For IGFBP7 the multivariable regression analysis was corrected for age, sex, eGFR, diabetes, smoking, dyslipidaemia, MI, AF, heart failure as identified in Table 1
  3. For GDF-15 the multivariable regression analysis was corrected for age, sex, eGFR, diabetes, smoking, dyslipidaemia, angina, MI, AF and COPD, as identified in Table 2
  4. Echo: included MFS and enlarged left atrial area in the regression analyses
  5. Biomarkers: included log-transformed hsTnT and log-transformed NTproBNP in the regression analysis