Association analysis of maternal MTHFR gene polymorphisms and the occurrence of congenital heart disease in offspring

Table 6 Hierarchical analysis for gene–gene interactions by using logistic regression

Variable 1	Variable2	Variable 3	OR (95% CI)^†	P
rs2066470-rs1801131 interaction
rs2066470	rs1801131
GG	TT		1
GA + AA	TT		1.69 (0.51–5.53)	0.390
GG	TG + GG		2.16 (1.41–3.30)	0.000
GA + AA	TG + GG		0.87 (0.59–1.29)	0.496
rs2274976-rs1801133-rs1801131 interaction
rs2274976	rs1801133	rs1801131
CC	GG	TT	1
CT + TT	GG	TT	–	–
CC	GG	TG + GG	2.08 (1.17–3.67)	0.012
CT + TT	GG	TG + GG	1.16 (0.68–2.01)	0.584
CC	GA + AA	TT	1.87 (1.24–2.82)	0.003
CT + TT	GA + AA	TT	0.91 (0.68–1.65)	0.511
CC	GA + AA	TG + GG	6.18 (2.83–13.51)	0.000
CT + TT	GA + AA	TG + GG	1.25 (0.69–2.28)	0.464

OR odds ratio, CI confidence interval
^†Adjusted for maternal education, family income, residence location, abnormal pregnancy history, family consanguineous marriage history, family congenital malformation history, personal lifestyle and habit before pregnancy, exposure history to environmentally hazardous substances as well as medicine history in this pregnancy

ISSN: 1471-2261