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Table 3 Associations of maternal MTHFR gene polymorphisms with risk of CHD based on multivariate logistic regression analysis

From: Association analysis of maternal MTHFR gene polymorphisms and the occurrence of congenital heart disease in offspring

SNPs

Total CHD†

ASD†

VSD†

PDA†

ORadj (95%CI)

P

FDR_P

ORadj (95%CI)

P

FDR_P

ORadj (95%CI)

P

FDR_P

ORadj (95%CI)

P

FDR_P

rs2274976

            

CC

1

  

1

  

1

  

1

  

CT

0.83 (0.61–1.14)

0.254

0.462

0.98 (0.57–1.67)

0.928

0.999

0.79 (0.56–1.12)

0.184

0.409

0.53 (0.31–0.89)

0.017

0.113

TT

1.01 (0.36–2.80)

0.987

0.987

-

0.999

0.999

1.39 (0.50–3.86)

0.534

0.763

1.26 (0.39–4.12)

0.699

0.873

Dominant model

0.84 (0.62–1.15)

0.278

0.397

0.92 (0.54–1.58)

0.768

0.913

0.83 (0.59–1.16)

0.267

0.445

0.59 (0.37–0.96)

0.033

0.083

Recessive model

1.05 (0.38–2.91)

0.925

0.925

-

0.999

0.999

1.45 (0.52–4.03)

0.473

0.676

1.37 (0.42–4.48)

0.606

0.673

Additive model

0.87 (0.66–1.15)

0.341

0.426

0.88 (0.53–1.45)

0.606

0.895

0.89 (0.66–1.20)

0.428

0.653

0.70 (0.46–1.06)

0.090

0.180

rs1801133

            

GG

1

  

1

  

1

  

1

  

GA

1.28 (0.98–1.66)

0.072

0.240

1.46 (0.91–2.35)

0.120

0.400

1.35 (1.01–1.81)

0.041

0.205

1.52 (1.03–2.24)

0.034

0.125

AA

1.22 (0.76–1.97)

0.410

0.547

1.75 (0.79–3.86)

0.166

0.463

1.05 (0.62–1.78)

0.852

0.949

0.89 (0.38–2.10)

0.786

0.873

Dominant model

1.27 (0.98–1.63)

0.069

0.230

1.50 (0.95–2.37)

0.079

0.225

1.30 (0.99–1.72)

0.064

0.213

1.44 (0.98–2.11)

0.060

0.120

Recessive model

1.08 (0.68–1.70)

0.742

0.824

1.45 (0.69–3.08)

0.329

0.823

0.90 (0.55–1.49)

0.687

0.859

0.71 (0.31–1.62)

0.412

0.515

Additive model

1.17 (0.96–1.43)

0.115

0.192

1.37 (0.97–1.93)

0.072

0.240

1.15 (0.93–1.43)

0.201

0.503

1.21 (0.89–1.63)

0.228

0.285

rs535107

            

AA

1

  

1

  

1

  

1

  

AG

1.16 (0.88–1.52)

0.285

0.407

1.53 (0.95–2.44)

0.078

0.400

1.03 (0.76–1.39)

0.854

0.949

1.15 (0.78–1.70)

0.472

0.640

GG

1.55 (0.93–2.59)

0.096

0.274

1.23 (0.48–3.15)

0.672

0.999

1.64 (0.96–2.80)

0.073

0.243

1.54 (0.78–3.05)

0.213

0.387

Dominant model

1.22 (0.94–1.57)

0.135

0.270

1.48 (0.94–2.33)

0.090

0.225

1.12 (0.85–1.48)

0.437

0.568

1.22 (0.84–1.75)

0.298

0.373

Recessive model

1.47 (0.89–2.43)

0.138

0.230

1.02 (0.41–2.56)

0.967

0.999

1.62 (0.96–2.74)

0.073

0.168

1.46 (0.75–2.83)

0.265

0.515

Additive model

1.20 (0.98–1.48)

0.074

0.247

1.29 (0.90–1.84)

0.166

0.415

1.16 (0.93–1.45)

0.178

0.503

1.20 (0.91–1.60)

0.201

0.285

rs4846052

            

CC

1

  

1

  

1

  

1

  

CT

1.56 (1.09–2.24)

0.015

0.100

1.64 (0.89–2.99)

0.110

0.400

1.28 (0.86–1.90)

0.219

0.438

0.94 (0.54–1.64)

0.831

0.875

TT

7.62 (2.95–19.65)

0.000

0.000

7.56 (2.39–23.90)

0.001

0.020

5.12 (1.92–13.65)

0.001

0.010

6.57 (2.34–18.44)

0.000

0.000

Dominant model

1.97 (1.41–2.75)

0.000

0.000

2.14 (1.25–3.66)

0.006

0.060

1.56 (1.09–2.24)

0.016

0.080

1.40 (0.87–2.24)

0.165

0.236

Recessive model

7.12 (2.76–18.33)

0.000

0.000

7.04 (2.23–22.16)

0.001

0.010

4.93 (1.85–13.13)

0.001

0.005

6.63 (2.37–18.54)

0.000

0.000

Additive model

1.96 (1.48–2.60)

0.000

0.000

2.14 (1.39–3.28)

0.001

0.010

1.62 (1.20–2.19)

0.002

0.010

1.61 (1.12–2.32)

0.011

0.050

rs1476413

            

CC

1

  

1

  

1

  

1

  

CT

0.97 (0.74–1.28)

0.819

0.862

1.25 (0.79–1.98)

0.349

0.635

0.71 (0.52–0.97)

0.031

0.205

0.86 (0.58–1.30)

0.480

0.640

TT

1.50 (0.92–2.45)

0.107

0.268

0.37 (0.09–1.61)

0.185

0.463

1.62 (0.97–2.72)

0.065

0.243

1.72 (0.92–3.21)

0.091

0.184

Dominant model

1.05 (0.81–1.36)

0.704

0.880

1.12 (0.71–1.76)

0.623

0.890

0.85 (0.64–1.13)

0.255

0.445

1.01 (0.69–1.46)

0.978

0.978

Recessive model

1.52 (0.94–2.46)

0.091

0.227

0.34 (0.08–1.45)

0.144

0.480

1.82 (1.09–3.01)

0.021

0.070

1.81 (0.98–3.32)

0.057

0.173

Additive model

1.11 (0.91–1.35)

0.314

0.449

0.97 (0.66–1.41)

0.862

0.895

1.01 (0.81–1.26)

0.910

0.910

1.13 (0.85–1.49)

0.399

0.443

rs4846048

            

AA

1

  

1

  

1

  

1

  

AG

1.09 (0.79–1.50)

0.622

0.732

1.14 (0.67–1.94)

0.635

0.999

1.13 (0.80–1.60)

0.484

0.755

1.45 (0.94–2.24)

0.092

0.184

GG

2.50 (1.11–5.63)

0.027

0.135

-

0.999

0.999

0.99 (0.37–2.69)

0.991

0.992

2.64 (1.00–6.95)

0.050

0.125

Dominant model

1.20 (0.89–1.63)

0.239

0.398

1.04 (0.61–1.77)

0.878

0.913

1.12 (0.80–1.56)

0.511

0.568

1.57 (1.05–2.37)

0.029

0.083

Recessive model

2.46 (1.09–5.54)

0.030

0.100

-

0.999

0.999

0.97 (0.36–2.63)

0.956

0.956

2.44 (0.93–6.38)

0.069

0.173

Additive model

1.26 (0.97–1.63)

0.085

0.170

0.95 (0.58–1.55)

0.829

0.895

1.09 (0.81–1.45)

0.575

0.653

1.53 (1.09–2.14)

0.015

0.050

rs2066470

            

GG

1

  

1

  

1

  

1

  

GA

0.90 (0.65–1.24)

0.505

0.631

1.35 (0.81–2.27)

0.251

0.502

0.92 (0.64–1.30)

0.628

0.794

0.60 (0.36–0.99)

0.048

0.125

AA

1.74 (0.65–4.66)

0.272

0.418

-

0.999

0.999

2.26 (0.87–5.86)

0.093

0.266

1.21 (0.34–4.27)

0.767

0.873

Dominant model

0.95 (0.69–1.29)

0.727

0.808

1.25 (0.75–2.09)

0.395

0.688

1.00 (0.72–1.40)

0.995

0.995

0.65 (0.40–1.04)

0.075

0.125

Recessive model

1.78 (0.67–4.75)

0.252

0.360

-

0.999

0.999

2.31 (0.89–5.96)

0.084

0.168

1.29 (0.37–4.57)

0.690

0.690

Additive model

1.00 (0.76–1.32)

0.983

0.983

1.12 (0.70–1.80)

0.643

0.895

1.08 (0.81–1.45)

0.588

0.653

0.74 (0.49–1.12)

0.150

0.250

rs3737964

            

CC

1

  

1

  

1

  

1

  

CT

1.26 (0.92–1.73)

0.154

0.308

1.37 (0.81–2.34)

0.242

0.502

1.13 (0.80–1.61)

0.481

0.755

1.63 (1.05–2.54)

0.030

0.125

TT

1.66 (0.69–3.96)

0.257

0.428

-

0.999

0.999

1.00 (0.37–2.69)

0.992

0.992

1.74 (0.61–4.99)

0.303

0.505

Dominant model

1.30 (0.95–1.76)

0.097

0.243

1.25 (0.74–2.11)

0.413

0.688

1.12 (0.80–1.57)

0.509

0.568

1.65 (1.08–2.50)

0.020

0.083

Recessive model

1.58 (0.66–3.78)

0.300

0.375

-

0.999

0.999

0.97 (0.36–2.63)

0.956

0.956

1.58 (0.55–4.50)

0.396

0.515

Additive model

1.27 (0.97–1.65)

0.079

0.198

1.10 (0.68–1.77)

0.707

0.895

1.09 (0.81–1.46)

0.575

0.653

1.50 (1.05–2.13)

0.025

0.063

rs1801131

            

TT

1

  

1

  

1

  

1

  

TG

1.30 (0.98–1.71)

0.067

0.268

1.48 (0.92–2.39)

0.105

0.400

1.12 (0.82–1.52)

0.491

0.755

1.48 (1.00–2.18)

0.050

0.125

GG

5.18 (2.77–9.71)

0.000

0.000

4.55 (1.67–12.34)

0.003

0.030

4.98 (2.66–9.33)

0.000

0.000

3.65 (1.63–8.18)

0.002

0.020

Dominant model

1.58 (1.22–2.06)

0.001

0.005

1.68 (1.07–2.65)

0.025

0.125

1.43 (1.08–1.90)

0.014

0.080

1.66 (1.14–2.40)

0.008

0.080

Recessive model

4.76 (2.56–8.85)

0.000

0.000

3.99 (1.49–10.71)

0.006

0.030

4.82 (2.59–8.98)

0.000

0.000

3.18 (1.44–7.02)

0.004

0.020

Additive model

1.68 (1.36–2.09)

0.000

0.000

1.75 (1.19–2.56)

0.004

0.020

1.59 (1.27–1.99)

0.000

0.000

1.67 (1.23–2.26)

0.001

0.010

rs1889292

            

CC

1

  

1

  

1

  

1

  

CT

0.96 (0.73–1.25)

0.742

0.824

0.98 (0.62–1.56)

0.933

0.999

0.80 (0.60–1.08)

0.139

0.348

0.98 (0.67–1.43)

0.903

0.903

TT

1.49 (0.86–2.59)

0.152

0.338

0.93 (0.31–2.82)

0.902

0.999

1.16 (0.64–2.11)

0.635

0.794

1.40 (0.67–2.93)

0.368

0.566

Dominant model

1.02 (0.79–1.32)

0.892

0.892

0.98 (0.62–1.53)

0.913

0.913

0.84 (0.64–1.12)

0.230

0.445

1.03 (0.71–1.48)

0.881

0.978

Recessive model

1.52 (0.89–2.60)

0.128

0.256

0.94 (0.32–2.80)

0.912

0.999

1.26 (0.70–2.27)

0.441

0.676

1.42 (0.69–2.91)

0.342

0.515

Additive model

1.08 (0.88–1.33)

0.477

0.530

0.98 (0.66–1.43)

0.895

0.895

0.92 (0.73–1.16)

0.490

0.653

1.08 (0.80–1.45)

0.619

0.619

  1. MTHFR Methylenetetraphydrofolate reductase, CHD congenital heart disease, ASD atrial septal defect, VSD ventricular septal defect, PDA patent ductus arteriosus, SNP single nucleotide polymorphism, ORadj adjusted odds ratio, CI confidence interval, FDR false discovery rate
  2. †Adjusted for maternal education, family income, residence location, abnormal pregnancy history, family consanguineous marriage history, family congenital malformation history, personal lifestyle and habit before pregnancy, exposure history to environmentally hazardous substances as well as medicine history in this pregnancy
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BMC Cardiovascular Disorders

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