Association analysis of maternal MTHFR gene polymorphisms and the occurrence of congenital heart disease in offspring

Table 2 Maternal MTHFR genotype frequencies and P values of HWE test

SNPs	Chromosome	Major allele	Minor allele	MAF	group	Genotype frequencies^†			HWE test P
SNPs	Chromosome	Major allele	Minor allele	MAF	group	AA	AB	BB	HWE test P
rs2274976	1:11790870	C	T	0.1183	Control	505 (77.5%)	136 (20.9%)	11 (1.7%)	0.5995
					Case	448 (78.7%)	111 (19.5%)	10 (1.8%)
rs1801133	1:11796321	G	A	0.3141	Control	308 (47.2%)	289 (44.3%)	55 (8.4%)	0.2651
					Case	245 (43.1%)	280 (49.2%)	44 (7.7%)
rs535107	1:11829411	A	G	0.2404	Control	402 (61.7%)	216 (33.1%)	34 (5.2%)	0.4798
					Case	314 (55.2%)	207 (36.4%)	48 (8.4%)
rs4846052	1:11797894	C	T	0.1057	Control	567 (87.0%)	79 (12.1%)	6 (0.9%)	0.0884
					Case	437 (76.8%)	97 (17.0%)	35 (6.2%)
rs1476413	1:11792243	C	T	0.2391	Control	399 (61.2%)	217 (33.3%)	36 (5.5%)	0.3668
					Case	330 (58.0%)	183 (32.2%)	56 (9.8%)
rs4846048	1:11786195	A	G	0.1212	Control	522 (80.1%)	119 (18.3%)	11 (1.7%)	0.1703
					Case	433 (76.1%)	117 (20.6%)	19 (3.3%)
rs4846051	1:11794400	A	G	0.0020	Control	649 (99.5%)	3 (0.5%)	0	0.9530
					Case	567 (99.6%)	2 (0.4%)	0
rs1931226	1:11803917	C	T	0.0012	Control	649 (99.5%)	3 (0.5%)	0	0.9530
					Case	569 (100.0%)	0	0
rs2066470	1:11803000	G	A	0.1167	Control	517 (79.3%)	126 (19.3%)	9 (1.4%)	0.0606
					Case	443 (77.9%)	111 (19.5%)	15 (2.6%)
rs3737964	1:11806987	C	T	0.1200	Control	523 (80.2%)	118 (18.1%)	11 (1.7%)	0.1544
					Case	430 (75.6%)	125 (22.0%)	14 (2.5%)
rs7525338	1:11802275	C	T	0.0020	Control	649 (99.5%)	3 (0.5%)	0	0.9530
					Case	567 (99.6%)	2 (0.4%)	0
rs1801131	1:11794419	T	G	0.2138	Control	448 (68.7%)	188 (28.8%)	16 (2.5%)	0.4750
					Case	323 (56.8%)	190 (33.4%)	56 (9.8%)
rs1889292	1:11780886	C	T	0.2445	Control	377 (57.8%)	246 (37.7%)	29 (4.4%)	0.1586
					Case	318 (55.9%)	209 (36.7%)	42 (7.4%)

MTHFR Methylenetetraphydrofolate reductase, SNP single nucleotide polymorphism, HWE Hardy–Weinberg equilibrium, MAF minimum allele frequency
^†AA = homozygous wild-type; AB = heterozygous variant type; BB = homozygous variant type

ISSN: 1471-2261