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Table 3 Cox regression models for prognostic prediction, divided with the internal quantile ranges of plasma osmolality on admission

From: Prognostic relevance of elevated plasma osmolality on admission in acute decompensated heart failure with preserved ejection fraction: insights from PURSUIT-HFpEF registry

  Unadjusted HR (95% CI) P-value
Composite endpoint   
Q2 versus Q1 1.13 (0.80–1.60) 1.0000
Q3 versus Q1 1.61 (1.16–2.23) 0.0120
Q3 versus Q2 1.42 (1.03–1.96) 0.0954
Cardiac mortality   
Q2 versus Q1 0.85 (0.42–1.66) 1.0000
Q3 versus Q1 1.59 (0.89–2.88) 0.3531
Q3 versus Q2 1.88 (1.01–3.61) 0.1338
HF re-admission   
Q2 versus Q1 1.12 (0.79–1.60) 1.0000
Q3 versus Q1 1.50 (1.08–2.11) 0.0504
Q3 versus Q2 1.34 (1.08–2.11) 0.2454
  1. HF, heart failure; HR, hazard ratio; Q1, plasma osmolality on admission < 293.2 mOsm/kg; Q2, plasma osmolality on admission ≥ 293.2 and < 300.3 mOsm/kg; and Q3, plasma osmolality on admission ≥ 300.3 mOsm/kg
  2. Cox proportional hazard models for composite endpoint, cardiac mortality and heart failure re-admission. Composite endpoint was defined as cardiac mortality or heart failure re-admission. P-value was corrected with Bonferroni adjustment