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Table 5 Cutoff values from receiver operating characteristic (ROC) curve analysis of mid LV short-axis ECV in myocardial disease and CAD

From: Native T1 mapping and extracellular volume fraction for differentiation of myocardial diseases from normal CMR controls in routine clinical practice

  Cutoff (%) AUC p-value Specificity (%)
(95% CI)
Sensitivity (%)
(95% CI)
PPV (%)
(95% CI)
NPV (%)
(95% CI)
Diagnostic Accuracy
(%) (95% CI)
Amyloidosis
Mid LV short-axis actual ECV (n = 8) 40.0 0.882 < 0.001 99.6 (98.4–99.9) 87.5 (52.9–97.8) 77.8 (45.3–93.7) 99.8 (98.8–100) 99.4 (98.2–99.8)
Mid LV short-axis synthetic ECV (n = 11) 32.6 0.910 < 0.001 97.6 (96.1–98.6) 81.8 (52.3–94.9) 39.1 (22.2–59.2) 99.7 (98.8–99.9) 97.4 (95.8–98.4)
DCM
Mid LV short-axis actual ECV (n = 116) 28.8 0.638 < 0.001 72.9 (68.7–76.7) 51.7 (42.7–60.6) 32.3 (26.0-39.3) 85.8 (82.0-88.9) 68.7 (64.8–72.3)
Mid LV short-axis synthetic ECV (n = 157) 27.0 0.675 < 0.001 55.6 (51.6–59.6) 72.6 (65.2–79.0) 30.2 (25.8–35.0) 88.5 (84.9–91.4) 59.2 (55.6–62.6)
HCM
Mid LV short-axis actual ECV (n = 84) 31.8 0.601 0.003 93.8 (91.2–95.6) 25.0 (17.0-35.2) 42.0 (29.4–55.8) 87.4 (84.2–90.0) 83.2 (79.9–86.1)
Mid LV short-axis synthetic ECV (n = 112) 29.7 0.670 < 0.001 83.7 (80.5–86.4) 46.4 (37.5–55.6) 34.9 (27.7–42.8) 89.2 (86.4–91.6) 77.8 (74.6–80.7)
Myocarditis
Mid LV short-axis actual ECV (n = 13) 30.5 0.625 0.124 85.4 (81.9–88.3) 53.8 (29.1–76.8) 9.3 (4.6–18.0) 98.5 (96.8–99.3) 84.5 (81.0-87.5)
Mid LV short-axis synthetic ECV (n = 17) 31.3 0.694 0.006 92.9 (90.6–94.7) 41.2 (21.6–64.0) 14.3 (7.1–26.7) 98.2 (96.8–99.0) 91.5 (89.0-93.5)
CAD
Mid LV short-axis actual ECV (n = 223) 27.9 0.559 0.012 65.4 (60.9–69.6) 49.3 (42.8–55.8) 40.6 (34.9–46.5) 72.9 (68.4–76.9) 60.2 (56.5–63.8)
Mid LV short-axis synthetic ECV (n = 293) 27.3 0.561 0.003 58.5 (54.5–62.4) 53.9 (48.2–59.5) 39.0 (34.4–43.8) 72.0 (67.9–75.9) 57.0 (53.7–60.2)
  1. A p-value < 0.05 indicates statistical significance
  2. CAD coronary heart disease, AUC area under the ROC curve, CI confidence interval, PPV positive predictive value, NPV negative predictive value, ECV extracellular volume fraction, DCM dilated cardiomyopathy, HCM hypertrophic cardiomyopathy