| Cutoff (%) | AUC | p-value | Specificity (%) (95% CI) | Sensitivity (%) (95% CI) | PPV (%) (95% CI) | NPV (%) (95% CI) | Diagnostic Accuracy (%) (95% CI) |
---|---|---|---|---|---|---|---|---|
Amyloidosis | ||||||||
Mid LV short-axis actual ECV (n = 8) | 40.0 | 0.882 | < 0.001 | 99.6 (98.4–99.9) | 87.5 (52.9–97.8) | 77.8 (45.3–93.7) | 99.8 (98.8–100) | 99.4 (98.2–99.8) |
Mid LV short-axis synthetic ECV (n = 11) | 32.6 | 0.910 | < 0.001 | 97.6 (96.1–98.6) | 81.8 (52.3–94.9) | 39.1 (22.2–59.2) | 99.7 (98.8–99.9) | 97.4 (95.8–98.4) |
DCM | ||||||||
Mid LV short-axis actual ECV (n = 116) | 28.8 | 0.638 | < 0.001 | 72.9 (68.7–76.7) | 51.7 (42.7–60.6) | 32.3 (26.0-39.3) | 85.8 (82.0-88.9) | 68.7 (64.8–72.3) |
Mid LV short-axis synthetic ECV (n = 157) | 27.0 | 0.675 | < 0.001 | 55.6 (51.6–59.6) | 72.6 (65.2–79.0) | 30.2 (25.8–35.0) | 88.5 (84.9–91.4) | 59.2 (55.6–62.6) |
HCM | ||||||||
Mid LV short-axis actual ECV (n = 84) | 31.8 | 0.601 | 0.003 | 93.8 (91.2–95.6) | 25.0 (17.0-35.2) | 42.0 (29.4–55.8) | 87.4 (84.2–90.0) | 83.2 (79.9–86.1) |
Mid LV short-axis synthetic ECV (n = 112) | 29.7 | 0.670 | < 0.001 | 83.7 (80.5–86.4) | 46.4 (37.5–55.6) | 34.9 (27.7–42.8) | 89.2 (86.4–91.6) | 77.8 (74.6–80.7) |
Myocarditis | ||||||||
Mid LV short-axis actual ECV (n = 13) | 30.5 | 0.625 | 0.124 | 85.4 (81.9–88.3) | 53.8 (29.1–76.8) | 9.3 (4.6–18.0) | 98.5 (96.8–99.3) | 84.5 (81.0-87.5) |
Mid LV short-axis synthetic ECV (n = 17) | 31.3 | 0.694 | 0.006 | 92.9 (90.6–94.7) | 41.2 (21.6–64.0) | 14.3 (7.1–26.7) | 98.2 (96.8–99.0) | 91.5 (89.0-93.5) |
CAD | ||||||||
Mid LV short-axis actual ECV (n = 223) | 27.9 | 0.559 | 0.012 | 65.4 (60.9–69.6) | 49.3 (42.8–55.8) | 40.6 (34.9–46.5) | 72.9 (68.4–76.9) | 60.2 (56.5–63.8) |
Mid LV short-axis synthetic ECV (n = 293) | 27.3 | 0.561 | 0.003 | 58.5 (54.5–62.4) | 53.9 (48.2–59.5) | 39.0 (34.4–43.8) | 72.0 (67.9–75.9) | 57.0 (53.7–60.2) |