Skip to main content

Table 4 Cutoff values from receiver operating characteristic (ROC) curve analysis of native T1 in myocardial disease and CAD

From: Native T1 mapping and extracellular volume fraction for differentiation of myocardial diseases from normal CMR controls in routine clinical practice

  Cutoff (ms) AUC p-value Specificity (%)
(95% CI)
Sensitivity (%)
(95% CI)
PPV (%)
(95% CI)
NPV (%)
(95% CI)
Diagnostic Accuracy
(%) (95% CI)
Amyloidosis (n = 11)
Mid LV short-axis native T1 1,341 0.990 < 0.001 93.9 (91.7–95.6) 100 (74.1–100.0) 23.4 (13.6–37.2) 100 (99.3–100) 94.1 (91.9–95.7)
Septum native T1 1,370 0.936 < 0.001 99.7 (98.8–99.9) 81.8 (52.3–94.9) 81.8 (52.3–94.9) 99.7 (98.8–99.9) 99.3 (98.3–99.7)
DCM (n = 157)
Mid LV short-axis native T1 1,338 0.783 < 0.001 90.9 (88.3–93.3) 56.1 (48.2–63.6) 62.0 (53.8–69.5) 88.7 (85.9–91.0) 83.6 (80.8–86.1)
Septum native T1 1,341 0.736 < 0.001 94.3 (92.1–95.9) 50.3 (42.6–58.0) 69.9 (60.9–77.6) 87.8 (85.0–90.1) 85.1 (82.4–87.5)
HCM (n = 112)
Mid LV short-axis native T1 1,333 0.723 < 0.001 86.9 (83.9–89.4) 53.6 (44.4–62.5) 43.5 (35.5–51.8) 90.9 (88.2–93.0) 81.6 (78.6–84.3)
Septum native T1 1,346 0.711 < 0.001 96.0 (94.1–97.3) 40.2 (31.6–49.4) 65.2 (53.4–75.4) 89.5 (86.9–91.6) 87.1 (84.5–89.4)
Myocarditis (n = 17)
Mid LV short-axis native T1 1,355 0.710 0.003 98.3 (96.9–99.1) 41.2 (21.6–64.0) 41.2 (21.6–64.0) 98.3 (96.9–99.1) 96.7 (95.0–97.9)
Septum native T1 1,360 0.752 < 0.001 99.2 (98.0–99.6) 35.3 (17.3–58.7) 54.5 (28.0–78.7) 98.2 (96.8–99.0) 97.4 (95.8–98.4)
CAD
Mid LV short-axis native T1 (n = 293) 1,342 0.621 < 0.001 94.3 (92.1–95.9) 30.7 (25.7–36.2) 72.6 (64.1–79.7) 73.4 (70.2–76.4) 73.3 (70.3–76.1)
Septum native T1 (n = 247) 1,343 0.618 < 0.001 94.6 (92.5–96.2) 28.7 (23.5–34.7) 68.9 (59.4–77.1) 76.2 (73.0–79.1) 75.3 (72.3–78.1)
  1. A p-value < 0.05 indicates statistical significance
  2. CAD coronary heart disease, AUC area under the ROC curve, CI confidence interval, PPV, positive predictive value, NPV negative predictive value, DCM dilated cardiomyopathy, HCM hypertrophic cardiomyopathy