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Table 3 Comparison of ECV using actual and synthetic Hct between myocardial disease or coronary artery disease and control group

From: Native T1 mapping and extracellular volume fraction for differentiation of myocardial diseases from normal CMR controls in routine clinical practice

Group

Mid LV short-axis ECV

with actual Hct

(%)

Septum ECV

with actual Hct

(%)

Mid LV short-axis ECV

with synthetic Hct

(%)

Septum ECV

with synthetic Hct

(%)

n

Mean ± SD

95% CI

p

n

Mean ± SD

95% CI

p

n

Mean ± SD

95% CI

P

n

Mean ± SD

95% CI

p

Amyloidosis (n = 8)

42.8 ± 9.0

35.3–50.3

0.002

(n = 8)

47.2 ± 10.5

38.4–56.0

0.001

(n = 11)

46.6 ± 13.0

38.9–54.3

0.001

(n = 11)

49.3 ± 11.8

41.4–57.2

< 0.001

DCM

(n = 116)

28.9 ± 4.1

28.1–29.6

< 0.001

(n = 116)

29.9 ± 4.5

29.1–30.8

< 0.001

(n = 157)

28.9 ± 3.6

28.4–29.5

< 0.001

(n = 157)

30.0 ± 3.9

29.4–30.6

< 0.001

HCM

(n = 84)

28.7 ± 4.6

27.7–29.7

0.002

(n = 84)

30.1 ± 4.6

29.1–31.1

< 0.001

(n = 112)

29.7 ± 5.7

28.6–30.7

< 0.001

(n = 112)

31.1 ± 5.8

30.0-32.2

< 0.001

Myocarditis (n = 13)

30.6 ± 7.8

25.9–35.4

0.126

(n = 13)

30.5 ± 5.7

27.1–34.0

0.125

(n = 17)

31.4 ± 7.7

27.7–35.1

0.030

(n = 17)

31.3 ± 5.3

28.6–34.1

0.014

CAD

(n = 223)

28.1 ± 5.0

27.5–28.7

0.006

(n = 186)

29.3 ± 5.5

28.5–30.1

0.002

(n = 293)

27.8 ± 4.3

27.3–28.3

0.002

(n = 247)

29.1 ± 4.9

28.5–29.7

< 0.001

Control

(n = 465)

27.1 ± 3.4

26.8–27.4

–

(n = 465)

27.9 ± 3.6

27.6–28.3

–

(n = 595)

26.9 ± 3.1

26.7–27.2

–

(n = 595)

27.0 ± 3.3

27.5–28.0

–

  1. A p-value < 0.05 indicates statistical significance
  2. ECV extracellular volume fraction, Hct hematocrit, CAD coronary artery disease, SD standard deviation, CI confidence interval, DCM dilated cardiomyopathy, HCM hypertrophic cardiomyopathy