Plasma uric acid is related to large arterial stiffness but not to other hemodynamic variables: a study in 606 normotensive and never-medicated hypertensive subjects

Table 4 Significant explanatory variables for aortic to popliteal pulse wave velocity in linear regression analysis with stepwise elimination

Pulse wave velocity (m/s)	B	Beta	p
Men and women, R² = 0.591
(constant)	7.594		< 0.001
Age	0.076	0.501	< 0.001
Ejection duration	− 0.020	− 0.223	< 0.001
Mean aortic pressure	0.022	0.180	< 0.001
Uric acid	0.004	0.168	< 0.001
Body mass index	0.032	0.077	0.019
Lg₁₀ of triglycerides	0.557	0.069	0.034
Current smoking	− 0.363	− 0.067	0.015
Women, R² = 0.580
(constant)	− 0.025
Age	0.073	0.524	< 0.001
Mean aortic pressure	0.023	0.221	< 0.001
Heart rate	0.032	0.187	< 0.001
Lg₁₀ of triglycerides	1.309	0.173	< 0.001
Uric acid	0.003	0.090	0.032
Men, R² = 0.532
(constant)	7.747		< 0.001
Age	0.084	0.481	< 0.001
Ejection duration	− 0.024	− 0.230	< 0.001
Uric acid	0.006	0.171	< 0.001
Mean aortic pressure	0.025	0.164	0.001
LDL cholesterol	0.255	0.113	0.014

Variables in Model: Age, sex, body mass index, alcohol consumption category (low, moderate, high), smoking status (current, previous), mean aortic pressure, heart rate, ejection duration, eGFR, uric acid, HDL cholesterol, LDL cholesterol; Lg₁₀ of triglycerides; Lg₁₀ of C-reactive protein, and QUICKI. HDL high-density lipoprotein, LDL low-density lipoprotein, QUICKI quantitative insulin sensitivity check index, eGFR estimated glomerular filtration rate from plasma cystatin-C using the CKD-EPI formula [22]

ISSN: 1471-2261