Table 2 Clinical characteristics and laboratory results of the study participants in age, sex and body mass index adjusted quartiles of fasting plasma uric acid concentrations

Office measurements

 Systolic BP (mmHg)

136 (1.5)

140 (1.5)

142 (1.5)

143 (1.5)*

 Diastolic BP (mmHg)

87 (0.9)

89 (0.9)

90 (0.9)*

91 (0.9)*

 Heart rate (bpm)

66.5 (0.8)

67.2 (0.8)

67.7 (0.8)

68.3 (0.9)

 Number (%) of participants with BP ≥ 140/90 mmHg

68 (48.2)

92 (59.4)

106 (64.2)*

89 (61.8)

Current smokers (number)

20

18

18

19

Alcohol (standard drinks/week)

2 [0–6]

2 [0–5]

3 [1–5]

3 [1–7]

Uric acid (µmol/l)

234 (4)

278 (4)*

314 (4)*^†

373 (4)*^†‡

Sodium (mmol/l)

140 (0.2)

141 (0.2)

140 (0.2)

140 (0.2)

Potassium (mmol/l)

3.8 (0.0)

3.8 (0.0)

3.8 (0.0)

3.8 (0.0)

Calcium (mmol/l)

2.29 (0.01)

2.30 (0.01)

2.31 (0.01)

2.32 (0.01)

Phosphate (mmol/l)

0.95 (0.01)

0.97 (0.01)

0.96 (0.01)

0.99 (0.01)

C-reactive protein (mg/l)

0.5 [0.5–1.4]

0.8 [0.5–1.8]

1.0 [0.5–2.1]

1.0 [0.5-2.1]*^†

Renin activity (ng Ang I/ml/h)

0.6 [0.3–1.1]

0.7 [0.4–1.2]

0.7 [0.5–1.3]

0.8 [0.5-1.3]

Aldosterone (pmol/l)

422 [292–569]

449 [329–609]

423 [320–572]

461 [338-620]

PTH (pmol/l)

4.32 (0.13)

4.51 (0.13)

4.75 (0.13)

4.66 (0.14)

eGFR (ml/min/1.73 m²)

102 (1.2)

100 (1.2)

97 (1.2)

98 (1.2)

Albumin excretion (µg/min)^a

4 [3–5]

4 [3–6]

4 [3–5]

4 [3–5]

Total cholesterol (mmol/l)

5.0 (0.1)

5.0 (0.1)

5.2 (0.1)

5.2 (0.1)

Triglycerides (mmol/l)

0.9 [0.6–1.2]

1.0 [0.7–1.3]

1.1 [0.8–1.5]*

1.2 [0.8–1.8]*^†

HDL cholesterol (mmol/l)

1.65 (0.03)

1.56 (0.03)

1.55 (0.03)

1.57 (0.03)

LDL cholesterol (mmol/l)

2.9 (0.1)

3.0 (0.1)

3.2 (0.1)*

3.1 (0.1)

Glucose (mmol/l)

5.4 (0.1)

5.4 (0.1)

5.4 (0.1)

5.5 (0.1)

Insulin (mU/l)

7.2 (1.4)

7.9 (1.4)

10.7 (1.4)

9.8 (1.5)

QUICKI

0.361 [0.342–0.381]

0.359 [0.367–0.376]

0.352 [0.332–0.372]

0.345 [0.324–0.373]*