Fig. 5

IL-17 induces cardiomyocyte apoptosis via STAT3 under both normoxia and hypoxia condition. (A, a, b, c) the normalized mRNA level of Bax, Bcl-2 and caspase3 after treated with IL-17 or STAT3 inhibitor under normoxia and hypoxia, respectively. ***p < 0.001, ****p < 0.0001 (vs control group). ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 (vs IL-17 group). B the protein expression of Bax, Bcl-2 and caspase3 after treated with IL-17 or STAT3 inhibitor under normoxia and hypoxia. (a) Western blot analysis of Bax, Bcl-2 and caspase-3. (b, c, d) Statistical bar graph for expression of Bax, Bcl-2 and caspase-3 respectively. **p < 0.01, ***p < 0.001 (vs control group). ^##p 0.01, ^###p < 0.001 (vs IL-17 group)